Table 5 Dataset of patient biopsies recruited in the study
Biopsy | Age | ECOG_PS | Status | T-Downstaging | N-Downstaging | Grade | Stage | Neoadjuvant treatment | Treatment toxicity | Pathological Response | Tumor size | DEK (% positive tumor cells) | Phospho-P38 (% positive tumor cells) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | > 70 | 1 | alive without disease | 0 | 1 | High | III | RDT + FOLFOX | No | Partial | > 3 cm | 3 | 35 |
2 | > 60 | 1 | alive without disease | 0 | 1 | High | III | RDT + 5FU | No | Minimum | > 3 cm | 3 | 35 |
3 | > 70 | 0 | Death | 1 | 0 | High | III | RDT + FOLFOX | Yes | Minimum | < 3 cm | 7 | 65 |
4 | > 70 | 0 | alive without disease | 0 | 1 | Low | III | RDT + 5FU | No | Minimum | > 3 cm | 10 | 80 |
5 | > 60 | 0 | alive with desease | 0 | 1 | Low | III | RDT + FOLFOX | Yes | Minimum | > 3 cm | 15 | 45 |
6 | > 70 | 0 | alive without disease | 1 | 1 | High | III | RDT + FOLFOX | Yes | Partial | > 3 cm | 15 | 80 |
7 | > 40 | 0 | alive with desease | 0 | 0 | High | III | RDT + 5FU | Yes | Partial | > 3 cm | 20 | 25 |
8 | > 40 | 1 | alive with desease | 1 | 0 | High | II | RDT + 5FU | Yes | Minimum | > 3 cm | 20 | 25 |
9 | > 70 | 0 | alive without disease | 1 | 1 | Low | III | RDT + 5FU | No | Partial | > 3 cm | 30 | 45 |
10 | > 70 | 0 | alive without disease | 1 | 1 | High | III | RDT + FOLFOX | Yes | Minimum | > 3 cm | 35 | 55 |
11 | > 70 | 0 | alive without disease | N/A | N/A | High | III | RDT + FOLFOX | No | Minimum | > 3 cm | 35 | 10 |
12 | > 50 | 0 | alive without disease | 0 | 1 | High | III | RDT + 5FU | Yes | Minimum | > 3 cm | 35 | 70 |
13 | > 70 | 0 | alive without disease | 1 | 1 | High | III | RDT + 5FU | No | Partial | > 3 cm | 35 | 25 |
14 | > 50 | 0 | alive without disease | 1 | 1 | Low | III | RDT + 5FU | No | Minimum | > 3 cm | 35 | 25 |
15 | > 70 | 1 | alive without disease | 1 | 1 | High | III | RDT + 5FU | Yes | Minimum | < 3 cm | 35 | 90 |
16 | > 60 | 1 | alive without disease | 1 | 1 | Low | III | RDT + 5FU | No | Partial | > 3 cm | 35 | 90 |
17 | > 60 | 0 | N/A | 0 | 0 | High | III | RDT + FOLFOX | Yes | Minimum | > 3 cm | 40 | 5 |
18 | > 80 | 0 | Death | 1 | 0 | High | III | RDT + 5FU | Yes | Partial | > 3 cm | 40 | 90 |
19 | > 70 | 1 | alive without disease | 0 | 1 | Low | III | RDT + 5FU | Yes | Minimum | > 3 cm | 40 | 85 |
20 | > 60 | 0 | alive without disease | 0 | 1 | High | III | RDT + 5FU | No | Minimum | > 3 cm | 40 | 65 |
21 | > 70 | 2 | alive without disease | 1 | 0 | N/A | II | RDT + 5FU | Yes | Minimum | > 3 cm | 40 | 100 |
22 | > 70 | 1 | Death | 0 | 1 | High | III | RDT + 5FU | Yes | Partial | > 3 cm | 45 | 65 |
23 | > 80 | 1 | alive without disease | N/A | N/A | High | III | RDT + 5FU | No | Partial | > 3 cm | 45 | 40 |
24 | > 70 | 1 | alive without disease | N/A | N/A | Low | III | RDT + 5FU | Yes | Partial | > 3 cm | 45 | 80 |
25 | > 80 | 1 | alive without disease | 1 | 1 | Low | III | RDT + 5FU | No | Partial | > 3 cm | 50 | 80 |
26 | > 70 | 1 | alive without disease | 1 | 1 | Low | III | RDT + 5FU | No | Partial | > 3 cm | 55 | 80 |
27 | > 50 | 0 | alive without disease | 1 | 1 | High | III | RDT + FOLFOX | Yes | Minimum | > 3 cm | 60 | 80 |
28 | > 80 | 1 | alive without disease | N/A | N/A | High | N/A | RDT + 5FU | No | Complete | > 3 cm | 60 | 60 |
29 | > 80 | 1 | alive without disease | 1 | 1 | High | III | RDT + FOLFOX | Yes | Minimum | > 3 cm | 60 | 75 |
30 | > 60 | 0 | alive without disease | 0 | 0 | High | III | RDT + 5FU | No | Minimum | > 3 cm | 60 | 40 |
31 | > 50 | 1 | alive with desease | 1 | 1 | High | III | RDT + 5FU | No | Complete | < 3 cm | 60 | 100 |
32 | > 60 | 0 | alive without disease | N/A | N/A | High | III | RDT + 5FU | No | Complete | > 3 cm | 60 | 45 |
33 | > 40 | 0 | alive without disease | 0 | 0 | High | III | RDT + FOLFOX | Yes | Minimum | > 3 cm | 65 | 100 |
34 | > 80 | 0 | alive without disease | 1 | 1 | High | III | RDT + 5FU | Yes | Partial | > 3 cm | 65 | 75 |
35 | > 80 | 0 | alive without disease | 1 | 0 | High | III | RDT + 5FU | No | Partial | > 3 cm | 65 | 75 |
36 | > 80 | 1 | alive without disease | 1 | 1 | N/A | III | RDT + 5FU | Yes | Partial | < 3 cm | 65 | 90 |
37 | > 70 | 0 | alive without disease | 1 | 1 | N/A | III | RDT + 5FU | No | Complete | > 3 cm | 65 | 90 |
38 | > 70 | 1 | alive without disease | 1 | 1 | Low | III | RDT + 5FU | No | Minimum | > 3 cm | 65 | 15 |
39 | > 60 | 0 | alive without disease | 1 | 1 | High | III | RDT + 5FU | No | Partial | > 3 cm | 65 | 80 |
40 | > 60 | 1 | alive without disease | 1 | 0 | High | III | RDT + 5FU | No | Partial | > 3 cm | 65 | 50 |
41 | > 40 | 0 | alive without disease | 1 | 1 | Low | III | RDT + 5FU | Yes | Partial | > 3 cm | 70 | 60 |
42 | > 80 | 1 | alive without disease | 1 | 1 | High | III | RDT + 5FU | No | Complete | > 3 cm | 75 | 80 |
43 | > 70 | 0 | alive with desease | 1 | 0 | Low | III | RDT + FOLFOX | No | Minimum | < 3 cm | 75 | 90 |
44 | > 70 | 1 | alive without disease | N/A | N/A | High | III | RDT + 5FU | No | Minimum | > 3 cm | 75 | 75 |
45 | > 40 | 0 | alive without disease | 1 | 1 | N/A | III | RDT + 5FU | No | Complete | > 3 cm | 75 | 95 |
46 | > 60 | 0 | alive without disease | 1 | 1 | Low | III | RDT + 5FU | Yes | Complete | < 3 cm | 75 | 90 |
47 | > 80 | 1 | alive without disease | 0 | 1 | High | III | RDT + 5FU | Yes | Minimum | > 3 cm | 75 | 95 |
48 | > 60 | 1 | alive with desease | 0 | 1 | High | III | RDT + 5FU | Yes | Complete | > 3 cm | 75 | 70 |
49 | > 70 | 0 | Death | 1 | 1 | Low | III | others | Yes | Minimum | < 3 cm | 80 | 3 |
50 | > 80 | 1 | Death | 0 | 0 | High | III | RDT + FOLFOX | Yes | Minimum | > 3 cm | 80 | 35 |
51 | > 70 | 0 | alive without disease | 0 | 0 | High | III | RDT + 5FU | No | Partial | > 3 cm | 80 | 100 |
52 | > 60 | 0 | alive without disease | 0 | 1 | High | III | RDT + 5FU | Yes | Partial | < 3 cm | 80 | 95 |
53 | > 70 | 1 | alive without disease | 1 | 0 | N/A | III | RDT + 5FU | No | Partial | > 3 cm | 80 | 30 |
54 | > 60 | 0 | alive without disease | 0 | 0 | N/A | II | RDT + 5FU | No | Partial | > 3 cm | 80 | 10 |
55 | > 70 | 1 | alive without disease | 1 | 1 | N/A | III | RDT + FOLFOX | No | Partial | > 3 cm | 85 | 90 |
56 | > 80 | 1 | alive without disease | 0 | 1 | High | III | RDT + 5FU | Yes | Minimum | > 3 cm | 85 | 45 |
57 | > 50 | 0 | alive without disease | 1 | 1 | Low | III | RDT + 5FU | No | Partial | > 3 cm | 85 | 75 |
58 | > 50 | 1 | alive without disease | 0 | 0 | High | III | RDT + 5FU | No | Minimum | > 3 cm | 85 | 85 |
59 | > 60 | 0 | alive without disease | 1 | 1 | Low | III | RDT + 5FU | No | Partial | > 3 cm | 85 | 30 |
60 | > 80 | 1 | alive without disease | 1 | 1 | High | III | RDT + 5FU | No | Minimum | > 3 cm | 85 | 80 |
61 | > 60 | 0 | alive without disease | 1 | 1 | Low | III | RDT + 5FU | No | Partial | > 3 cm | 85 | 0 |
62 | > 50 | 0 | alive without disease | N/A | N/A | Low | III | RDT + FOLFOX | No | Minimum | > 3 cm | 85 | 100 |
63 | > 70 | 1 | alive without disease | 1 | 1 | High | III | RDT + 5FU | No | Minimum | N/A | 90 | 95 |
64 | > 70 | 0 | alive without disease | 0 | 1 | High | III | RDT + 5FU | No | Minimum | > 3 cm | 90 | 85 |
65 | > 70 | 1 | Death | 0 | 0 | High | III | RDT + 5FU | Yes | Minimum | > 3 cm | 90 | 45 |
66 | > 50 | 0 | alive without disease | 1 | 1 | Low | III | RDT + 5FU | No | Minimum | > 3 cm | 90 | 55 |
67 | > 60 | 2 | Death | 0 | 0 | High | III | RDT + 5FU | Yes | Minimum | > 3 cm | 95 | 100 |
68 | > 70 | 0 | alive without disease | 1 | 0 | N/A | II | RDT + 5FU | No | Minimum | > 3 cm | 95 | 85 |
69 | > 60 | 0 | alive without disease | 0 | 1 | High | III | RDT + 5FU | No | Partial | > 3 cm | 95 | 80 |
70 | > 60 | 0 | alive without disease | 0 | 1 | High | III | RDT + 5FU | Yes | Minimum | > 3 cm | 95 | 90 |
71 | > 70 | 0 | alive with desease | 0 | 1 | High | III | RDT + 5FU | No | Minimum | > 3 cm | 95 | 75 |
72 | > 70 | 0 | alive without disease | 1 | 0 | High | III | RDT + 5FU | No | Complete | > 3 cm | 95 | 75 |
73 | > 80 | 1 | alive without disease | 0 | 1 | High | III | RDT + 5FU | No | Minimum | > 3 cm | 100 | 75 |
74 | > 50 | 1 | alive without disease | 0 | 1 | High | III | RDT + 5FU | No | Minimum | > 3 cm | 100 | 80 |