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Table 2 Results of the Meta-analysis

From: HtrA1 as a promising tissue marker in cancer: a meta-analysis

  POOLED ANALYSIS HETEROGENEITY PUBLICATION BIAS  
  ES (CI) P-value Q I 2 P-value T 2 T Egger’s Begg and Mazdumdar’s  
T P-value Z P-value  
Cancer vs Healthy Controls
 Protein (k = 3)
[13,41,39]
2.91 (1.80;4.70) < 0.0001 1.68 0.00 0.432 0.00 0.00 Fig. 1
 mRNA (k = 3)
[39–41]
3.93 (2.17;7.15) < 0.0001 2.12 5.81 0.346 0.02 0.14 Fig. 1
Cancer vs Normal-Looking Tissue
 Protein
(k = 6)
[9,12,13,17,35,36]
2.93 (2.21;3.90) < 0.0001 4.42 0.00 0.491 0.00 0.00 −1.10 0.334 −1.32 0.188 Fig. 2a, b
 mRNA
(k = 5)
[12,17,34–36]
2. 80 (1.81;4.32) < 0.0001 9.01 55.59 0.061 0.14 0.37 0.28 0.798 0.00 1.000 Fig. 2a, c
SURVIVAL
 Protein
(k = 5) [10,15,35,36,38]
0.51 (0.37;0.70) 0.005 2.29 0.00 0.682 0.00 0.00 0.14 0.897 0.49 0.624 Fig. 3a, b
 mRNA
(k = 2) [11,36]
0.57 (0.31;1.06) 0.076 1.21 17.03 0.272 0.04 0.19 Fig. 3a