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Table 1 Characteristics of the studies included in the meta-analysis

From: HtrA1 as a promising tissue marker in cancer: a meta-analysis

TUMOR SITE PATIENT POPULATION   HtrA1 RESULTS
  Cancer and Normal-looking Healthy controls Setting Laboratory Normalization  
    Tumor Marker Prognostic Marker Protein mRNA Housekeeping Healthy tissues  
Colo-rectum
[13]
N = 37
M = 22 F = 15
mean age ± sd
65.5 ± 9.4
N = 36
M = 13 F = 23
mean age ± sd 53.3 ± 10.0
     Differences between cancer and healthy control tissue p = 0.0001
Difference between cancer and normal-looking tissue p = 0.001
Liver
[12]
N = 60
M = 25 F = 35,
mean age 51.5

GADPH
  Difference between cancer and normal-looking tissue p < 0.0001
Stomach
[34]
N = 42
M = 22
mean age ± sd 53.4 ± 9.9
F = 20
mean age ± sd 50.3 ± 14.1

B-ACTIN
  Normal gastric tissue, positive staining 83.3%
Tumor tissue, negative staining 95.0%
Bladder
[17]
N = 68,
M = 50 F = 18
mean age ± sd
68.2 ± 7.0

B-ACTIN
Difference between cancer and normal-looking tissue p < 0.0001 for protein. Difference for mRNA not significant p = 0.422
Breast
[11]
N = 131 all females  
GADPH
  Better survival in high expression OS HR 0.45 (0.23–0.90) p = 0.023
Esophagus
[Yu] [35]
N = 63
M = 50 F = 10
mean age 73.4 range 45–79

GADPH B-ACTIN
Difference between cancer and normal-looking tissue p < 0.05 as protein, p = 0.004 as mRNA
Esophagus
[Xia] [36]
N = 115
Age < 60 N = 52
Age > 60 N = 63

B-ACTIN
  Difference between cancer and normal-looking tissue p < 0.05 both protein and mRNA
Better survival in high expression OS: HR 0.75 (95 CI 0.38–1.4) p = 0.433a
Liver
[37]
N = 50
M = 42
mean age ± sd 52.4 ± 9.9
F = 8
mean age ± sd 50.3 ± 14.1
Difference between cancer and normal-looking tissue p = 0.45
Better survival in high expression: OS: HR 0.59 (95 CI 0.14–2.37) p = 0.486a
Stomach
[38]
N = 80 M = 51, F = 29
mean age, 64 range, 32–82
     OS: HR 0.55 (95% CI 0.32–0.96) p = 0.037
Thyroid
[9]
N = 20 age not reported     
GADPH
Not statistically significant
Endometrium [Mullany] [10] N = 184
mean age ± sd 66.1 ± 11.3
   
B-ACTIN
  OS HR: 0.29 (95% CI 0.023–3.75) p = 0.037
Endometrium [Narkiewicz]
[39]
N = 36 all females, age not reported N = 88 all females, age not reported  
B-ACTIN
  Difference between cancer and healthy control tissue p < 0.0001
Endometrium [Bowden]
[40]
N = 15 all females, age not reported N = 4 all females, age not reported   
GADPH
  HtrA1 mRNA significantly lower in tumor than in normal endometrium (p < 0.0001)
Pleura
[15]
N = 70
F = 29, M = 41
median age, 65 range, 45–81
     HtrA1 (+): HR 1 (reference category) HtrA1 (++): HR 0.65 (95% CI 0.348–0.876) HtrA1 (+++): HR 0.26 (95% CI 0.122–0.454) p < 0.00
Ovary
[41]
N = 44 all females, age not reported N = 19 all females, age not reported  
B-ACTIN
  HtrA1 mRNA significantly decreased in tumor compared with normal ovarian tissue (p < 0.0001) but not for HtrA1 protein (p = 0.452)
  1. M Males, F Females, (y) years, sd standard deviation, OS overall survival
  2. aThe hazard ratio (HR) and 95% Confidence Interval (CI) were used as a measure of effect size. When the HR and 95% CI were not reported in the publications, they were estimated from the Kaplan-Meier curves according to Parmar et al. [28], Tierney et al. [29], and Williamson et al. [30]
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