From: Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM
Pathway | Metabolite | 1D GC-MS | p-value | 2D GC-MS | p-value | AA Analysis | p-value |
---|---|---|---|---|---|---|---|
Alanine And Aspartate Metabolism | Aspargine | ↑ | 0.097 | ↑ | 0.077 | ||
Alanine | ↑ | 0.051 | ↑ | 0.274 | ↑ | 0.274 | |
Aspartic Acid | ↑ | 0.068 | ↑ | 0.356 | |||
Beta-Alanine | ↑ | 0.511 | ↑ | 0.354 | |||
Linoleic Acid Metabolism | Linoleic Acid | ↑ | 0.324 | ||||
Amino Sugar Metabolism | N-Acetyl Glucosamine | ↓ | 0.080 | ||||
Beta-Alanine Metabolism | Pantothenic Acid | ↓ | 0.080 | ||||
Citric Acid Cycle | Alpha-Ketoglutaric Acid | ↓ | 0.127 | ↓ | 0.047 | ||
Citric Acid | ↓ | 0.263 | |||||
Fumaric Acid | ↑ | 0.329 | |||||
Creatine Metabolism | Creatinine | ↓ | 0.165 | ↓ | 0.042 | ||
Cysteine | ↓ | 0.113 | ↑ | 0.200 | |||
Cysteine And Methionine Metabolism | Methionine | ↓ | 0.382 | ↓ | 0.619 | ||
Dipeptide | Glycylvaline | ↑ | 0.168 | ||||
Fatty Acid Biosynthesis | Dodecanoic Acid | ↓ | 0.649 | ||||
Hexadecanoic Acid | ↓ | 0.336 | |||||
Mannose | ↓ | 0.252 | |||||
Fructose And Mannose Degradation | Sorbitol-6-Phosphate (Fragment) | ↑ | 0.600 | ||||
Galactose Metabolism | Galactose | ↓ | 0,407 | ||||
Glutamate Metabolism | Glutamic Acid | ↑ | 0.535 | ↑ | 0.195 | ||
Glutamine | ↑ | 0.651 | ↑ | 0.412 | |||
GABA | ↓ | 0.466 | |||||
Glutathione Metabolism | Pyroglutamic Acid | ↓ | 0.366 | ↓ | 0.125 | ||
Glycerol Phosphate Shuttle | Glycerol-2-Phosphate | ↑ | 0.184 | ||||
Glycerol-3-Phosphate | ↑ | 0.005 | ↑ | 0.003 | |||
Glycerolipid Metabolism | Ethanolamine | ↑ | 0.658 | ||||
Serine | ↓ | 0.081 | ↓ | 0.553 | |||
Glycine, Serine And Threonine Metabolism | Glycine | ↓ | 0.487 | ↓ | 0.085 | ↓ | 0.157 |
Threonine | ↓ | 0.301 | ↑ | 0.033 | |||
Sarcosine | ↑ | 0.197 | |||||
Glycolysis, Gluconeogenesis, | Fructose-6-Phosphate | ↑ | 0.103 | ||||
Pyruvate Metabolism | Glucose | ↓ | 0.341 | ||||
Glycolysis, Gluconeogenesis, | Glucose-6-Phosphate | ↑ | 0.174 | ||||
Pyruvate Metabolism | Glyceric Acid | ↑ | 0.011 | ||||
Glyceric Acid-2-Phosphate | ↑ | 0.227 | |||||
Glyceric Acid-3-Phosphate | ↑ | 0.320 | ↑ | 0.228 | |||
Pyruvic Acid | ↓ | 0.049 | ↓ | 0.000 | |||
Homocysteine Degradation | 3-Methyl-2-Ketobutyric Acid | ↑ | 0.051 | ||||
Inositol Metabolism | Inositol | ↓ | 0.066 | ||||
Lysine Metabolism | Lysine | ↓ | 0.128 | ↑ | 0.404 | ||
Lysine 2 Derivative | ↑ | 0.128 | |||||
2-Amino-Adipic Acid | ↑ | 0.043 | |||||
Nicotinate And Nicotinamide Metabolism | Nicotinamide | ↓ | 0.371 | ||||
Nucleotide Sugar, Pentose Metabolism | Arabitol | ↑ | 0.294 | ||||
Oxidative Phosphorylation | Pyrophosphate | ↑ | 0.377 | ||||
Pentose Phosphate Pathway | Erythrose-4-Phosphate | ↑ | 0.007 | ||||
Glucaric Acid 1,4 Lactone | ↓ | 0.622 | |||||
Ribofuranose | ↓ | 0.213 | |||||
Ribose | ↓ | 0.359 | |||||
Ribose-5-Phosphate | ↑ | 0.137 | |||||
Polyamine Metabolism | Putrescine | ↓ | 0.653 | ||||
Spermidine | ↑ | 0.244 | |||||
Purine Metabolism | Adenine | ↓ | 0.265 | ||||
Hypoxanthine | ↑ | 0.119 | |||||
Pyrimidine Metabolism | Uracil | ↑ | 0.445 | ||||
Uridine | ↑ | 0.001 | |||||
Sugar, Sugar Substitute, Starch | Erythritol | ↓ | 0.270 | ||||
Taurine And Hypotaurine Metabolism | Taurine | ↑ | 0.282 | ||||
Tryptophan Metabolism | Tryptophan | ↑ | 0.104 | ||||
Tyrosine Metabolism | Tyrosine | ↓ | 0.221 | ↓ | 0.759 | ||
Urea Cycle, Arginine and | Ammonia | ↑ | 0.258 | ||||
Proline Metabolism | Arginine | ↑ | 0.251 | ↑ | 0.502 | ||
(Arginine biosynthetic pathway) | Asymetrical-N,N-Dimethylarginine | ↑ | 0.253 | ||||
Citrulline (Arginine) | ↑ | 0.247 | |||||
Citrulline (Ornthine) | ↑ | 0.193 | |||||
Citrulline | ↑ | 0.122 | |||||
N-Acetylornithine | ↓ | 0.370 | |||||
Ornithine | ↑ | 0.313 | ↑ | 0.219 | ↑ | 0.010 | |
2-Oxoisocaproic Acid | ↑ | 0.600 | |||||
Valine, Leucine And Isoleucine Degradation | Isoleucine | ↓ | 0.156 | ↓ | 0.550 | ||
Leucine | ↓ | 0.367 | |||||
Valine | ↓ | 0.085 | |||||
Other | 1,2-Ethandimine | ↓ | 0.007 | ||||
1,3,5-Trioxepane | ↓ | 0.085 | |||||
1-Mo nostearoylgly cer o l | ↓ | 0.373 | |||||
2-Pyrrolidone-5-Carboxylic Acid | ↓ | 0.179 | |||||
Aminomalonic Acid | ↓ | 0.252 | |||||
Cadaverine | ↑ | 0.289 | |||||
Cellotriose | ↑ | 0.042 | |||||
Dihydroxyacetonephosphate | ↑ | 0.096 | ↑ | 0.195 | |||
Elaidic Acid | ↑ | 0.165 | |||||
Glucopyranose | ↑ | 0.198 | |||||
N-Acetyl Glutamyl Phosphate | ↑ | 0.362 | |||||
Nonanoic Acid | ↓ | 0.264 | ↓ | 0.144 | |||
Phosphoric Acid | ↑ | 0.013 | |||||
Pyrazine | ↓ | 0.179 | |||||
Stearic Acid | ↑ | 0.357 | |||||
Xylitol | ↓ | 0.233 |