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Table 2 Metabolites affected in the cell pellet

From: Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM

Pathway

Metabolite

1D GC-MS

p-value

2D GC-MS

p-value

AA Analysis

p-value

Alanine And Aspartate Metabolism

Aspargine

0.097

  

0.077

Alanine

0.051

0.274

0.274

Aspartic Acid

  

0.068

0.356

Beta-Alanine

0.511

0.354

  

Linoleic Acid Metabolism

Linoleic Acid

  

0.324

  

Amino Sugar Metabolism

N-Acetyl Glucosamine

0.080

    

Beta-Alanine Metabolism

Pantothenic Acid

  

0.080

  

Citric Acid Cycle

Alpha-Ketoglutaric Acid

0.127

0.047

  

Citric Acid

  

0.263

  

Fumaric Acid

  

0.329

  

Creatine Metabolism

Creatinine

0.165

0.042

  

Cysteine

0.113

  

0.200

Cysteine And Methionine Metabolism

Methionine

  

0.382

0.619

Dipeptide

Glycylvaline

0.168

    

Fatty Acid Biosynthesis

Dodecanoic Acid

0.649

    

Hexadecanoic Acid

0.336

    

Mannose

0.252

    

Fructose And Mannose Degradation

Sorbitol-6-Phosphate (Fragment)

0.600

    

Galactose Metabolism

Galactose

0,407

    

Glutamate Metabolism

Glutamic Acid

0.535

  

0.195

Glutamine

0.651

  

0.412

GABA

    

0.466

Glutathione Metabolism

Pyroglutamic Acid

0.366

0.125

  

Glycerol Phosphate Shuttle

Glycerol-2-Phosphate

0.184

    

Glycerol-3-Phosphate

0.005

0.003

  

Glycerolipid Metabolism

Ethanolamine

0.658

    

Serine

  

0.081

0.553

Glycine, Serine And Threonine Metabolism

Glycine

0.487

0.085

0.157

Threonine

  

0.301

0.033

Sarcosine

0.197

    

Glycolysis, Gluconeogenesis,

Fructose-6-Phosphate

0.103

    

Pyruvate Metabolism

Glucose

0.341

    

Glycolysis, Gluconeogenesis,

Glucose-6-Phosphate

0.174

    

Pyruvate Metabolism

Glyceric Acid

0.011

    

Glyceric Acid-2-Phosphate

  

0.227

  

Glyceric Acid-3-Phosphate

0.320

0.228

  

Pyruvic Acid

0.049

0.000

  

Homocysteine Degradation

3-Methyl-2-Ketobutyric Acid

  

0.051

  

Inositol Metabolism

Inositol

0.066

    

Lysine Metabolism

Lysine

  

0.128

0.404

Lysine 2 Derivative

    

0.128

2-Amino-Adipic Acid

  

0.043

  

Nicotinate And Nicotinamide Metabolism

Nicotinamide

  

0.371

  

Nucleotide Sugar, Pentose Metabolism

Arabitol

0.294

    

Oxidative Phosphorylation

Pyrophosphate

  

0.377

  

Pentose Phosphate Pathway

Erythrose-4-Phosphate

  

0.007

  

Glucaric Acid 1,4 Lactone

0.622

    

Ribofuranose

  

0.213

  

Ribose

  

0.359

  

Ribose-5-Phosphate

0.137

    

Polyamine Metabolism

Putrescine

0.653

    

Spermidine

0.244

    

Purine Metabolism

Adenine

  

0.265

  

Hypoxanthine

  

0.119

  

Pyrimidine Metabolism

Uracil

0.445

    

Uridine

0.001

    

Sugar, Sugar Substitute, Starch

Erythritol

  

0.270

  

Taurine And Hypotaurine Metabolism

Taurine

    

0.282

Tryptophan Metabolism

Tryptophan

    

0.104

Tyrosine Metabolism

Tyrosine

  

0.221

0.759

Urea Cycle, Arginine and

Ammonia

    

0.258

Proline Metabolism

Arginine

0.251

  

0.502

(Arginine biosynthetic pathway)

Asymetrical-N,N-Dimethylarginine

0.253

    

Citrulline (Arginine)

0.247

    

Citrulline (Ornthine)

0.193

    

Citrulline

    

0.122

N-Acetylornithine

    

0.370

Ornithine

0.313

0.219

0.010

2-Oxoisocaproic Acid

0.600

    

Valine, Leucine And Isoleucine Degradation

Isoleucine

  

0.156

0.550

Leucine

  

0.367

  

Valine

    

0.085

Other

1,2-Ethandimine

  

0.007

  

1,3,5-Trioxepane

  

0.085

  

1-Mo nostearoylgly cer o l

  

0.373

  

2-Pyrrolidone-5-Carboxylic Acid

  

0.179

  

Aminomalonic Acid

  

0.252

  

Cadaverine

0.289

    

Cellotriose

0.042

    

Dihydroxyacetonephosphate

0.096

0.195

  

Elaidic Acid

  

0.165

  

Glucopyranose

  

0.198

  

N-Acetyl Glutamyl Phosphate

    

0.362

Nonanoic Acid

0.264

0.144

  

Phosphoric Acid

  

0.013

  

Pyrazine

  

0.179

  

Stearic Acid

  

0.357

  

Xylitol

0.233

    
  1. ↑ Elevated in ASS+ve cell lines, ↓ lowered in ASS+ve cell lines. p-values was calculated using a Mann-Whitney U-test