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Table 2 Metabolites affected in the cell pellet

From: Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM

Pathway Metabolite 1D GC-MS p-value 2D GC-MS p-value AA Analysis p-value
Alanine And Aspartate Metabolism Aspargine 0.097    0.077
Alanine 0.051 0.274 0.274
Aspartic Acid    0.068 0.356
Beta-Alanine 0.511 0.354   
Linoleic Acid Metabolism Linoleic Acid    0.324   
Amino Sugar Metabolism N-Acetyl Glucosamine 0.080     
Beta-Alanine Metabolism Pantothenic Acid    0.080   
Citric Acid Cycle Alpha-Ketoglutaric Acid 0.127 0.047   
Citric Acid    0.263   
Fumaric Acid    0.329   
Creatine Metabolism Creatinine 0.165 0.042   
Cysteine 0.113    0.200
Cysteine And Methionine Metabolism Methionine    0.382 0.619
Dipeptide Glycylvaline 0.168     
Fatty Acid Biosynthesis Dodecanoic Acid 0.649     
Hexadecanoic Acid 0.336     
Mannose 0.252     
Fructose And Mannose Degradation Sorbitol-6-Phosphate (Fragment) 0.600     
Galactose Metabolism Galactose 0,407     
Glutamate Metabolism Glutamic Acid 0.535    0.195
Glutamine 0.651    0.412
GABA      0.466
Glutathione Metabolism Pyroglutamic Acid 0.366 0.125   
Glycerol Phosphate Shuttle Glycerol-2-Phosphate 0.184     
Glycerol-3-Phosphate 0.005 0.003   
Glycerolipid Metabolism Ethanolamine 0.658     
Serine    0.081 0.553
Glycine, Serine And Threonine Metabolism Glycine 0.487 0.085 0.157
Threonine    0.301 0.033
Sarcosine 0.197     
Glycolysis, Gluconeogenesis, Fructose-6-Phosphate 0.103     
Pyruvate Metabolism Glucose 0.341     
Glycolysis, Gluconeogenesis, Glucose-6-Phosphate 0.174     
Pyruvate Metabolism Glyceric Acid 0.011     
Glyceric Acid-2-Phosphate    0.227   
Glyceric Acid-3-Phosphate 0.320 0.228   
Pyruvic Acid 0.049 0.000   
Homocysteine Degradation 3-Methyl-2-Ketobutyric Acid    0.051   
Inositol Metabolism Inositol 0.066     
Lysine Metabolism Lysine    0.128 0.404
Lysine 2 Derivative      0.128
2-Amino-Adipic Acid    0.043   
Nicotinate And Nicotinamide Metabolism Nicotinamide    0.371   
Nucleotide Sugar, Pentose Metabolism Arabitol 0.294     
Oxidative Phosphorylation Pyrophosphate    0.377   
Pentose Phosphate Pathway Erythrose-4-Phosphate    0.007   
Glucaric Acid 1,4 Lactone 0.622     
Ribofuranose    0.213   
Ribose    0.359   
Ribose-5-Phosphate 0.137     
Polyamine Metabolism Putrescine 0.653     
Spermidine 0.244     
Purine Metabolism Adenine    0.265   
Hypoxanthine    0.119   
Pyrimidine Metabolism Uracil 0.445     
Uridine 0.001     
Sugar, Sugar Substitute, Starch Erythritol    0.270   
Taurine And Hypotaurine Metabolism Taurine      0.282
Tryptophan Metabolism Tryptophan      0.104
Tyrosine Metabolism Tyrosine    0.221 0.759
Urea Cycle, Arginine and Ammonia      0.258
Proline Metabolism Arginine 0.251    0.502
(Arginine biosynthetic pathway) Asymetrical-N,N-Dimethylarginine 0.253     
Citrulline (Arginine) 0.247     
Citrulline (Ornthine) 0.193     
Citrulline      0.122
N-Acetylornithine      0.370
Ornithine 0.313 0.219 0.010
2-Oxoisocaproic Acid 0.600     
Valine, Leucine And Isoleucine Degradation Isoleucine    0.156 0.550
Leucine    0.367   
Valine      0.085
Other 1,2-Ethandimine    0.007   
1,3,5-Trioxepane    0.085   
1-Mo nostearoylgly cer o l    0.373   
2-Pyrrolidone-5-Carboxylic Acid    0.179   
Aminomalonic Acid    0.252   
Cadaverine 0.289     
Cellotriose 0.042     
Dihydroxyacetonephosphate 0.096 0.195   
Elaidic Acid    0.165   
Glucopyranose    0.198   
N-Acetyl Glutamyl Phosphate      0.362
Nonanoic Acid 0.264 0.144   
Phosphoric Acid    0.013   
Pyrazine    0.179   
Stearic Acid    0.357   
Xylitol 0.233     
  1. ↑ Elevated in ASS+ve cell lines, ↓ lowered in ASS+ve cell lines. p-values was calculated using a Mann-Whitney U-test