From: Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM
Pathway | Metabolite | 1D GC-MS | p-value | 2D GC-MS | p-value | AA Analysis | p-value |
---|---|---|---|---|---|---|---|
Alanine And Aspartate Metabolism | Aspargine | ↑ | 0.000 | ↑ | 0.002 | ||
Alanine | ↑ | 0.000 | ↑ | 0.007 | |||
Aspartic Acid | ↑ | 0.029 | ↓ | 0.135 | |||
Amino Sugar Metabolism | N-Acetyl Glucosamine | ↑ | 0.000 | ||||
N-Acetyl Mannosamine | ↑ | 0.000 | |||||
Beta-Alanine Metabolism | Pantothenic Acid | ↓ | 0.292 | ↑ | 0.009 | ||
Citric Acid Cycle | Succinic Acid | ↑ | 0.010 | ||||
Creatine Metabolism | Creatinine | ↑ | 0.003 | ||||
Cystein | ↑ | 0.121 | |||||
Cysteine And Methionine Metabolism | Cystein (2 Derivative) | ↑ | 0.005 | ||||
Cystine | ↑ | 0.005 | ↑ | 0.003 | |||
Methionine | ↑ | 0.003 | ↑ | 0.044 | |||
Fatty Acid Biosynthesis | 3-Hydroxybutyric Acid | ↑ | 0.004 | ||||
Butanoic Acid | ↑ | 0.000 | |||||
Hexadecanoic Acid | ↓ | 0.200 | |||||
Fructose-1- Phosphate | ↑ | 0.050 | |||||
Fructose And Mannose Degradation | Mannose | ↓ | 0.020 | ||||
Fructose | ↑ | 0.011 | |||||
Galactose Metabolism | Galactose | ↓ | 0.225 | ||||
Glutamate Metabolism | Glutamic Acid | ↑ | 0.000 | ↑ | 0.247 | ||
GABA | ↑ | 0.001 | |||||
Glutamine | ↑ | 0.000 | ↑ | 0.009 | |||
Glutathione Metabolism | Pyroglutamic Acid | ↑ | 0.000 | ||||
Glycerolipid Metabolism | Ethanolamine | ↑ | 0.010 | ||||
Glycine, Serine And Threonine Metabolism | Glycine | ↑ | 0.068 | ↑ | 0.012 | ↑ | 0.152 |
Sarcosine | ↑ | 0.000 | |||||
Serine | ↑ | 0.007 | ↑ | 0.020 | |||
Threonine | ↑ | 0.017 | ↑ | 0.155 | |||
Glycolysis. Gluconeogenesis. | Glucose | ↓ | 0.143 | ||||
Pyruvate Metabolism | Glyceric Acid | ↑ | 0.000 | ||||
Lactic Acid | ↑ | 0.002 | |||||
Malic Acid | ↑ | 0.039 | |||||
Histidine Metabolism | Histidine | ↑ | 0.033 | ↑ | 0.027 | ||
Homocysteine Degradation | 3-Methyl-2-Ketobutyric Acid | ↑ | 0.000 | ||||
Inositol Metabolism | Inositol | ↑ | 0.002 | ||||
Lysine Metabolism | Lysine | ↑ | 0.044 | ↑ | 0.008 | ↑ | 0.191 |
Lysine (2 Derivative) | ↑ | 0.027 | |||||
Nicotinate And Nicotinamide Metabolism | Nicotinamide | ↑ | 0.021 | ↑ | 0.001 | ||
Arabinose | ↑ | 0.003 | |||||
Nucleotide Sugar. Pentose Metabolism | Arabitol | ↑ | 0.000 | ||||
Nucleotide Sugars Metabolism | Xylose | ↑ | 0.004 | ||||
Pentose Phosphate Pathway | Gluconic Acid 1.4-Lactone | ↑ | 0.034 | ||||
Ribofuranose | ↑ | 0.013 | |||||
Ribose | ↑ | 0.000 | ↑ | 0.028 | |||
Sedoheptulose-7-Phosphate | ↑ | 0.276 | |||||
Phenylalanine Metabolism | Phenylalanine | ↑ | 0.000 | ↑ | 0.022 | ||
Purine Metabolism | Allantoin | ↑ | 0.051 | ||||
Pyrimidine Metabolism | Uracil | ↓ | 0.024 | ||||
Riboflavin Metabolism | Ribitol | ↑ | 0.000 | ||||
Sugar. Sugar Substitute. Starch | Erythritol | ↑ | 0.002 | ||||
Tryptophan Metabolism | Tryptophan | ↑ | 0.035 | ||||
Tyrosine Metabolism | Tyrosine | ↑ | 0.034 | ↑ | 0.010 | ↑ | 0.052 |
Urea Cycle. Arginine and Proline Metabolism | Ammonia | ↓ | 0.038 | ||||
Arginine | ↑ | 0.015 | ↑ | 0.010 | ↑ | 0.070 | |
(Arginine biosynthetic pathway) | Argininosuccinate | ↑ | 0.021 | ||||
Asymetrical-N.N- Dimethylarginine | ↑ | 0.018 | |||||
Citrulline | ↑ | 0.098 | |||||
Citrulline (Arginine) | ↑ | 0.016 | |||||
Citrulline (Ornthine) | ↑ | 0.019 | |||||
Hydroxyproline | ↑ | ||||||
Ornithine (2 Derivative) | ↑ | 0.000 | |||||
Ornithine | ↑ | 0.006 | ↑ | 0.156 | |||
Proline | ↑ | 0.000 | ↑ | 0.000 | |||
Urea | ↑ | 0.058 | ↑ | 0.001 | |||
2-Keto-3-Methylvaleric Acid | ↑ | 0.002 | |||||
Valine. Leucine And Isoleucine Degradation | 2-Oxoisocaproic Acid | ↑ | 0.002 | ↑ | 0.000 | ||
Isoleucine | ↑ | 0.008 | ↑ | 0.033 | ↓ | 0.373 | |
Leucine | ↑ | 0.056 | ↓ | 0.253 | |||
Valine | ↑ | 0.010 | ↑ | 0.002 | ↓ | 0.132 | |
Other | 2-Aminobutyric Acid | ↑ | 0.000 | ||||
2-Deoxy-Galactose | ↑ | 0.002 | |||||
Allothreonine | ↑ | 0.010 | ↑ | 0.000 | |||
Cellotriose | ↓ | 0.224 | |||||
Ellagic Acid | ↓ | 0.293 | |||||
Gluconic Acid | ↓ | 0.095 | |||||
Isoerythritol | ↑ | 0.000 | |||||
Mannitol | ↓ | 0.031 | |||||
Pentanoic Acid | ↑ | 0.000 | |||||
Propanoic Acid | ↑ | 0.001 | |||||
Silanamine | ↑ | 0.021 | |||||
Sorbose | ↑ | 0.002 | |||||
Xylitol | ↑ | 0.000 |