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Table 5 Association between GC rs2282679 genotypes and overall and disease free colorectal cancer survival stratified by non-genetic dietary factors

From: Association of rs2282679 A>C polymorphism in vitamin D binding protein gene with colorectal cancer risk and survival: effect modification by dietary vitamin D intake

  GC rs2282679 genotype P interaction b
  AA
HR (95% CI)a
AC + CC
HR (95% CI)a
Disease-Free Survival   
 Dietary vitamin D (μg/d)    
  Highest tertile (≥7.1) 1.00 1.65 (0.97–2.82)  
  Lowest tertile (< 4.6) 1.03 (0.58–1.83) 1.08 (0.56–2.08) 0.191
 Dietary calcium (mg/d)    
  Highest tertile (≥1120.2) 1.00 1.58 (0.92–2.71)  
  Lowest tertile (< 702.1) 1.06 (0.59–1.91) 1.14 (0.62–2.11) 0.355
 Milk (g/d)    
  Highest tertile (≥274.6) 1.00 1.63 (0.92–1.84)  
  Lowest tertile (< 128.1) 1.21 (0.68–2.16) 0.97 (0.51–1.84) 0.083
 Total dairy products (g/d)    
  Highest tertile (≥411.8) 1.00 1.51 (0.87–2.60)  
  Lowest tertile (< 199.2) 1.00 (0.57–1.77) 0.99 (0.53–1.83) 0.289
Overall Survival    
 Dietary vitamin D (μg/d)    
  Highest tertile (≥7.1) 1.00 2.11 (1.29–3.74)  
  Lowest tertile (< 4.6) 1.28 (0.68–2.42) 1.11 (0.54–2.27) 0.040
 Dietary calcium (mg/d)    
  Highest tertile (≥1120.2) 1.00 1.93 (1.08–3.46)  
  Lowest tertile (< 702.1) 1.55 (0.82–2.91) 1.18 (0.59–2.35) 0.043
 Milk (g/d)    
  Highest tertile (≥274.6) 1.00 2.36 (1.26–4.44)  
  Lowest tertile (< 128.1) 2.09 (1.09–4.02) 1.26 (0.61–2.62) 0.004
 Total dairy products (g/d)    
  Highest tertile (≥411.8) 1.00 2.03 (1.11–3.72)  
  Lowest tertile (< 199.2) 1.77 (0.94–3.33) 1.27 (0.63–2.58) 0.024
  1. Abbreviations: HR hazard rate ratios, CI confidence interval
  2. aAdjusted for sex, age at diagnosis, stage at diagnosis, marital status, race, reported chemoradiotherapy, MSI status, BRAF mutation status, tumor location, body mass index where applicable
  3. bP for interaction is computed with Wald method testing significance of multiplicative interaction term between GC SNP rs2282679 genotype and respective stratified variable
  4. Those with P < 0.05 are in bold