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Table 5 Association between GC rs2282679 genotypes and overall and disease free colorectal cancer survival stratified by non-genetic dietary factors

From: Association of rs2282679 A>C polymorphism in vitamin D binding protein gene with colorectal cancer risk and survival: effect modification by dietary vitamin D intake

 

GC rs2282679 genotype

P interaction b

 

AA

HR (95% CI)a

AC + CC

HR (95% CI)a

Disease-Free Survival

  

 Dietary vitamin D (μg/d)

   

  Highest tertile (≥7.1)

1.00

1.65 (0.97–2.82)

 

  Lowest tertile (< 4.6)

1.03 (0.58–1.83)

1.08 (0.56–2.08)

0.191

 Dietary calcium (mg/d)

   

  Highest tertile (≥1120.2)

1.00

1.58 (0.92–2.71)

 

  Lowest tertile (< 702.1)

1.06 (0.59–1.91)

1.14 (0.62–2.11)

0.355

 Milk (g/d)

   

  Highest tertile (≥274.6)

1.00

1.63 (0.92–1.84)

 

  Lowest tertile (< 128.1)

1.21 (0.68–2.16)

0.97 (0.51–1.84)

0.083

 Total dairy products (g/d)

   

  Highest tertile (≥411.8)

1.00

1.51 (0.87–2.60)

 

  Lowest tertile (< 199.2)

1.00 (0.57–1.77)

0.99 (0.53–1.83)

0.289

Overall Survival

   

 Dietary vitamin D (μg/d)

   

  Highest tertile (≥7.1)

1.00

2.11 (1.29–3.74)

 

  Lowest tertile (< 4.6)

1.28 (0.68–2.42)

1.11 (0.54–2.27)

0.040

 Dietary calcium (mg/d)

   

  Highest tertile (≥1120.2)

1.00

1.93 (1.08–3.46)

 

  Lowest tertile (< 702.1)

1.55 (0.82–2.91)

1.18 (0.59–2.35)

0.043

 Milk (g/d)

   

  Highest tertile (≥274.6)

1.00

2.36 (1.26–4.44)

 

  Lowest tertile (< 128.1)

2.09 (1.09–4.02)

1.26 (0.61–2.62)

0.004

 Total dairy products (g/d)

   

  Highest tertile (≥411.8)

1.00

2.03 (1.11–3.72)

 

  Lowest tertile (< 199.2)

1.77 (0.94–3.33)

1.27 (0.63–2.58)

0.024

  1. Abbreviations: HR hazard rate ratios, CI confidence interval
  2. aAdjusted for sex, age at diagnosis, stage at diagnosis, marital status, race, reported chemoradiotherapy, MSI status, BRAF mutation status, tumor location, body mass index where applicable
  3. bP for interaction is computed with Wald method testing significance of multiplicative interaction term between GC SNP rs2282679 genotype and respective stratified variable
  4. Those with P < 0.05 are in bold