Association of rs2282679 A>C polymorphism in vitamin D binding protein gene with colorectal cancer risk and survival: effect modification by dietary vitamin D intake

Table 4 Association between GC SNP rs2282679 genotypes and overall and disease free colorectal cancer survival (overall and stratified by tumor molecular phenotype)

rs2282679 Genotype/Allele	Disease-Free Survival		P _interaction ^c	Overall Survival		P _interaction ^c
rs2282679 Genotype/Allele	No. of Events^a /At Risk	HR (95% CI)^b	P _interaction ^c	No. of Events^a /At Risk	HR (95% CI)^b	P _interaction ^c
Total colorectal cancer
AA	83/245	1.00		69/245	1.00
AC	80/207	1.33 (0.94–1.88)		68/208	1.24 (0.85–1.81)
CC	16/36	1.93 (1.06–3.52)		13/36	1.60 (0.85–3.02)
P _trend^d		0.020			0.107
CC + AC (vs. AA)	96/243	1.40 (1.00–1.95)		81/244	1.29 (0.90–1.85)
CC (vs. AC + AA)	16/36	1.69 (0.95–2.99)		13/36	1.44 (0.79–2.65)
Per C allele		1.36 (1.05–1.77)			1.26 (0.95–1.66)
BRAF Val600Glu mutant
AA	8/20	1.00		5/20	1.00
CC + AC^e	8/26	0.95 (0.25–3.62)		7/26	1.53 (0.47–4.95)
BRAF wild-type
AA	65/200	1.00		55/200	1.00
CC + AC ^e	83/195	1.58 (1.12–2.23)	0.043	70/196	1.33 (0.93–1.91)	0.892
MSI-H
AA	3/25	1.00		0/26	1.00
CC + AC^e	5/28	1.26 (0.18–8.96)		3/28	NC^f
MSS/MSI-L
AA	76/204	1.00		65/204	1.00
CC + AC^e	87/203	1.34 (0.97–1.87)	0.702	74/204	1.26 (0.89–1.77)	0.210

Abbreviations: HR hazard rate ratios, CI confidence interval, MSI-H microsatellite instability-high, MSS/MSI-L microsatellite stable/microsatellite instability-low
^aEvents are defined as deaths for overall survival and death, recurrence, or metastasis (whichever occurred earliest) for disease-free survival
^bMultivariable Cox model adjusted for sex, age at diagnosis, tumor stage at diagnosis, marital status, race, reported chemoradiotherapy, MSI status, BRAF mutation status, tumor location, fruit intake, and body mass index where applicable
^cP for interaction is computed with Wald method testing significance of multiplicative interaction term between GC SNP rs2282679 genotype and molecular subtype
^dLinear trend tested by modeling the ordinal variables of genotype dose as a continuous variable
^eCC and AC genotypes were analyzed jointly because of limited sample size in some subgroups
^fNC: not calculated
Those with P < 0.05 are in bold

ISSN: 1471-2407