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Table 3 Risk estimates for interactions between GC rs2282679 genotypes and non-genetic dietary factors

From: Association of rs2282679 A>C polymorphism in vitamin D binding protein gene with colorectal cancer risk and survival: effect modification by dietary vitamin D intake

  GC rs2282679 genotype P interaction b
  AA
OR (95% CI)a
AC + CC
OR (95% CI)a
Total vitamin D intake (μg/d)    
 Highest tertile (≥10.1) 1.00 1.65 (1.01–2.71)  
 Lowest tertile (< 5.0) 2.50 (1.52–4.09) 1.72 (1.03–2.90) 0.019
Total calcium intake (mg/d)    
 Highest tertile (≥1195.4) 1.00 1.45 (0.89–2.36)  
 Lowest tertile (< 761.4) 1.21 (0.73–2.00) 1.63 (0.95–2.81) 0.827
Milk (g/d)    
 Highest tertile (≥321.3) 1.00 1.61 (0.99–2.61)  
 Lowest tertile (< 146.5) 1.46 (0.90–2.38) 1.21 (0.72–2.04) 0.056
Total dairy products (g/d)    
 Highest tertile (≥432.0) 1.00 1.61 (0.99–2.61)  
 Lowest tertile (< 210.6) 1.44 (0.90–2.32) 1.27 (0.75–2.14) 0.079
  1. Abbreviations: CRC colorectal cancer, OR odds ratio
  2. aAdjusted for age, sex, family history of CRC, screening procedure, folic acid intake, smoking history, and education attainment where applicable
  3. bP for interaction is computed with Wald method testing significance of multiplicative interaction term between GC SNP rs2282679 genotype and respective stratified variable
  4. Those with P < 0.05 are in bold