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Table 5 Copy number variations (CNVs) in cohorts 1 and 2 at AKAP containing loci

From: Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs)

  

P1

P2

P3

P4

P5

P8

# Amp in cohort 2

# Del in cohort 2

Gene

Chr region

Primary

Metastasis

Primary

Metastasis

Primary

Metastasis

Primary

Metastasis

Primary

Metastasis

Primary

Metastasis

Primary

Metastasis

Primary

Metastasis

AKAP1

17q22

       

amp

    

10

11

  

AKAP5

14q23

     

del

        

0

1

AKAP6

14q12

     

del

      

4

5

  

AKAP7

6q23.2

del

del

 

del

    

del

del

  

1

4

0

2

AKAP8

19q13.12

       

amp

    

6

9

 

1

AKAP11

13q14.11

del

del

   

del

     

del

0

2

  

AKAP12

6q25.1

del

del

 

del

    

del

del

  

0

2

2

3

  1. CNV in cohort 1 were determined by calculating the normalized read coverage at each SNP position for paired tumor and germline samples, then taking the log2 of the ratio of these numbers and recentering to zero (see also Additional file 4: Figure S1 and Additional file 3: Figure S2)
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BMC Cancer

ISSN: 1471-2407

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