Skip to main content

Advertisement

Springer Nature is making Coronavirus research free. View research | View latest news | Sign up for updates

Table 4 List of AKAP nonsynonymous somatic mutations in cohort 2

From: Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs)

Gene Position CytoBand Mutation Exon A.A substitution Protein region SIFT Prediction Primary VAF Axillary lymph VAF Metastasis 1 VAF Metastasis 2 VAF Patient
AKAP1             
AKAP2             
AKAP3 chr12:4725047 12p13.32 G > A 5/5 Ser807Leu NA damaging 2% 13% 41%, 22%a pat 19
AKAP4 chrX:49958130 Xp11.22 A > G 5/6 Phe412Leu NA damaging 0% 0% 22%b 26% pat 8
AKAP5             
AKAP6             
AKAP7             
AKAP8             
AKAP9 chr7:91630327 7q21.2 A > G 8/50 Ile366Val close to bindning domain tolerated 4% 24%, 36%a   pat 7
AKAP10             
AKAP11 chr13:42875448 13q14.11 G > A 8/13 Asp856Asn NA tolerated 0% 8%   pat 12
AKAP12             
AKAP13             
AKAP14             
  1. Tumor cell fraction was determined by a clinical pathologist using blinded sample IDs
  2. amultiple blocks from same sample
  3. blocoregional metastasis