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Table 2 Correlation of CK1α RNA expression levels with clinical parameters

From: CK1α overexpression correlates with poor survival in colorectal cancer

  Total N low CK1α expression [RQ < 2.6] N (median RQ) high CK1α expression [RQ > =2.6] N (median RQ) median CK1α expression RQ (min-max) p value
Overall Survival
 Dead 120 46 (1.69) 74 (4.70) 3.23 (0.49–59.92) 0.036*
 Alive 163 88 (1.61) 75 (5.06) 2.46 (0.34–67.42)
Gender
 Male 160 71 (1.66) 89 (4.87) 2.89 (0.49–67.42) 0.364
 Female 123 63 (1.63) 60 (4.85) 2.54 (0.34–59.92)
Differentiation
 Low-grade (G1, G2) 209 115 (1.65) 94 (4.58) 2.43 (0.34–67.42) < 0.001**
 High-grade (G3, G4) 71 19 (1.67) 52 (5.38) 4.17 (0.77–53.30)
 n.d. 3 3 (8.11) 8.11 (3.24–8.31)  
Stage (UICC)
 0 4 1 (1.71) 3 (8.31) 6.38 (1.71–10.09)  
 I 62 27 (1.69) 35 (4.84) 2.78 (0.64–67.42) 0.611
 II, III 146 74 (1.63) 72 (4.76) 2.50 (0.34–59.92)
 IV 71 32 (1.61) 39 (5.07) 2.98 (0.53–53.30)
Localization
 Left colon 160 76 (1.70) 84 (4.90) 2.71 (0.34–67.42) 0.523
 Right colon 119 57 (1.63) 62 (4.70) 2.84 (0.53–15.58)
 n.d. 4 1 (2.39) 3 (7.03) 5.21 (2.39–9.72)  
 Total 283 134 (1.66) 149 (4.87) 2.76 (0.34–67.42)  
  1. Clinical parameters referring to CK1α RNA expression levels, calculated as relative quantification (RQ) by qPCR using HPRT as reference gene
  2. Statistical analysis was performed using median test. *p < 0.05; ***p < 0.001
  3. Abbreviations: G Grade, n.d not determined