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Table 3 Multivariate Cox regression analysis for recurrence and distant metastasis based on 244 cases with complete data for all variables

From: Performance of a prognostic 31-gene expression profile in an independent cohort of 523 cutaneous melanoma patients

  Univariate Multivariatea
HR 95% CI P value HR 95% CI P value
RFS
 Breslow 1.3 1.2–1.3 < 0.001 1.2 1.1–1.3 < 0.001
 Mitotic rate ≥ 1/mm2 3.3 1.9–5.7 < 0.001 0.9 0.5–1.7 0.8
 Ulceration present 4.5 3.2–6.5 < 0.001 1.4 0.8–2.2 0.2
 SLN positive 3.5 2.4–5.1 < 0.001 2.5 1.6–4.0 < 0.001
 GEP Class 2 5.4 3.7–7.7 < 0.001 2.1 1.3–3.4 0.003
DMFS
 Breslow 1.4 1.3–1.5 < 0.001 1.3 1.2–1.4 < 0.001
 Mitotic rate ≥ 1/mm2 3.9 2.0–7.5 < 0.001 0.9 0.5–2.0 0.9
 Ulceration present 4.8 3.2–7.2 < 0.001 1.2 0.7–2.1 0.5
 SLN positive 3.8 2.5–5.9 < 0.001 3.0 1.7–5.2 < 0.001
 GEP Class 2 6.6 4.3–10.2 < 0.001 2.7 1.5–4.8 0.002
  1. CI confidence interval, DMFS distant metastasis-free survival, GEP gene expression profile, RFS recurrence-free survival
  2. aThe multivariate Cox regression model includes data from 244 of 523 cases with complete information for Breslow thickness, mitotic rate, ulceration, SLN status and GEP class