Skip to main content
Fig. 4 | BMC Cancer

Fig. 4

From: Performance of a prognostic 31-gene expression profile in an independent cohort of 523 cutaneous melanoma patients

Fig. 4

Clinical utility of gene expression profiling with sentinel lymph node biopsy (SLNB). A schematic of the enhanced identification of high-risk melanoma patients when gene expression profiling is used in combination with SLNB prognostication. With SLNB only, sensitivities for all recurrences [local recurrence (LR) and distant metastasis (DM)] or distant metastases only (DM) are 65% or 67%, respectively (above dotted line). Inclusion of GEP identifies as high risk an additional 29 recurrences and 23 distant metastases, improving overall sensitivity of recurrences to 88%, and sensitivity of distant metastases to 91%. Similarly, the negative predictive value (NPV) is also improved when combining SLNB with the GEP test

Back to article page