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Table 4 Pathobiological and TIL characteristics of lymphocyte-poor (non-lyDCIS) and lymphocyte-rich non-invasive DCIS (lyDCIS)

From: Analysis of tumour-infiltrating lymphocytes reveals two new biologically different subgroups of breast ductal carcinoma in situ

 

non-lyDCIS

(n = 58)

lyDCIS

(n = 38)

p value

Characteristic

 Lesion size (mm)

11 ± 14

13 ± 19

NS

 Lesions ≥20 mm

11 (18.6%)

11 (28.9%)

NS

Architectural pattern

 comedo

9 (15.5%)

17 (44.7%)

0.0016

 solid

18 (31.0%)

12 (31.6%)

NS

 cribriform

29 (50.0%)

21 (55.3%)

NS

 micropapillary

23 (39.7%)

8 (21.1%)

NS

Presence of necrosis

32 (55.2%)

29 (82.9%)

0.0065

Presence of microcalcifications

44 (75.9%)

27 (75.0%)

NS

Nuclear grade

 low

14 (24.1%)

0 (0%)

0.001

 intermediate

29 (50.0%)

16 (42.1%)

NS

 high

15 (25.9%)

22 (57.9%)

0.0016

Mitotic index

2.4 ± 2.7

5.8 ± 4.7

<  0.001

Ki67 index

3.4 ± 4.4

6.9 ± 9.9

NS

Molecular subtype

 luminal

45 (77.6%)

22 (57.9%)

 

 HER2

4 (6.9%)

13 (34.2%)

0.0059*

 triple negative

9 (15.5%)

3 (7.9%)

 

TIL density (TIL-d)

 grade 0

15

0

NA

 grade 1

43

0

NA

 grade 2

0

28

NA

 grade 3

0

10

NA

TIL phenotype

 cells CD8+

42 ± 64

102 ± 113

0.0002

 cells CD4+

68 ± 138

165 ± 229

0.0018

 cells FoxP3+

7 ± 15

47 ± 54

<  0.0001

 cells CD20+

57 ± 123

253 ± 411

0.00013

 cells CD38+

19 ± 33

41 ± 43

0.00051

 T/B ratio

9.0 [6.2–11.7]

4.6 [2.4–11.7]

0.029

 CD8+/FoxP3+ ratio

8.2 [5.1–11.3]

11.6 [0.8–22.4]

NS

  1. Legend: Values given for individual lymphocyte subpopulations are mean ± SD; values for the ratios of lymphocyte counts are means and 95% CI. Abbreviations: NA not applicable, NS not significant, * = p value for the difference in global distribution of molecular subtypes between non-lyDCIS and lyDCIS