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Table 4 Pathobiological and TIL characteristics of lymphocyte-poor (non-lyDCIS) and lymphocyte-rich non-invasive DCIS (lyDCIS)

From: Analysis of tumour-infiltrating lymphocytes reveals two new biologically different subgroups of breast ductal carcinoma in situ

  non-lyDCIS
(n = 58)
lyDCIS
(n = 38)
p value
Characteristic
 Lesion size (mm) 11 ± 14 13 ± 19 NS
 Lesions ≥20 mm 11 (18.6%) 11 (28.9%) NS
Architectural pattern
 comedo 9 (15.5%) 17 (44.7%) 0.0016
 solid 18 (31.0%) 12 (31.6%) NS
 cribriform 29 (50.0%) 21 (55.3%) NS
 micropapillary 23 (39.7%) 8 (21.1%) NS
Presence of necrosis 32 (55.2%) 29 (82.9%) 0.0065
Presence of microcalcifications 44 (75.9%) 27 (75.0%) NS
Nuclear grade
 low 14 (24.1%) 0 (0%) 0.001
 intermediate 29 (50.0%) 16 (42.1%) NS
 high 15 (25.9%) 22 (57.9%) 0.0016
Mitotic index 2.4 ± 2.7 5.8 ± 4.7 <  0.001
Ki67 index 3.4 ± 4.4 6.9 ± 9.9 NS
Molecular subtype
 luminal 45 (77.6%) 22 (57.9%)  
 HER2 4 (6.9%) 13 (34.2%) 0.0059*
 triple negative 9 (15.5%) 3 (7.9%)  
TIL density (TIL-d)
 grade 0 15 0 NA
 grade 1 43 0 NA
 grade 2 0 28 NA
 grade 3 0 10 NA
TIL phenotype
 cells CD8+ 42 ± 64 102 ± 113 0.0002
 cells CD4+ 68 ± 138 165 ± 229 0.0018
 cells FoxP3+ 7 ± 15 47 ± 54 <  0.0001
 cells CD20+ 57 ± 123 253 ± 411 0.00013
 cells CD38+ 19 ± 33 41 ± 43 0.00051
 T/B ratio 9.0 [6.2–11.7] 4.6 [2.4–11.7] 0.029
 CD8+/FoxP3+ ratio 8.2 [5.1–11.3] 11.6 [0.8–22.4] NS
  1. Legend: Values given for individual lymphocyte subpopulations are mean ± SD; values for the ratios of lymphocyte counts are means and 95% CI. Abbreviations: NA not applicable, NS not significant, * = p value for the difference in global distribution of molecular subtypes between non-lyDCIS and lyDCIS