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Table 3 Pathobiological and TIL characteristics of pure DCIS (DCIS) and microinvasive carcinomas (miCa)

From: Analysis of tumour-infiltrating lymphocytes reveals two new biologically different subgroups of breast ductal carcinoma in situ

  DCIS
(n = 96)
miCa
(n = 35)
p value
Characteristic
 Lesion size (mm) 12 ± 16 14 ± 20 NS
 Lesions ≥20 mm 21 (21.9%) 10 (28.6%) NS
Architectural pattern
 comedo 26 (27.1) 14 (40.0%) NS
 solid 30 (31.3%) 16 (45.7%) NS
 cribriform 50 (52.1%) 15 (42.9%) NS
 micropapillary 31 (32.3%) 7 (20.0%) NS
 Presence of necrosis 61 (65.6%) 27 (77.1%) NS
 Presence of microcalcifications 71 (75.5%) 27 (77.1%) NS
Nuclear grade
 low 14 (14.6%) 2 (6.3%) NS
 intermediate 45 (46.9%) 12 (34.3%) NS
 high 37 (38.5%) 21 (60.0%) 0.029
 Mitotic index 3.7 ± 4.0 4.8 ± 4.4 NS
 Ki67 index 4.8 ± 7.3 5.6 ± 6.4 NS
Molecular subtype
 luminal 67 (68.9%) 15 (42.9%)  
 HER2 17 (17.7%) 11 (31.4%) 0.032*
 triple negative 12 (12.5%) 9 (25.7%)  
TIL density (TIL-d)
 grade 0 15 (15.6%) 1 (2.9%) NS (0.07)
 grade 1 43 (44.8%) 16 (45.7%) NS
 grade 2 28 (29.2%) 9 (25.7%) NS
 grade 3 10 (10.4%) 9 (25.7%) 0.028
TIL phenotype
 cells CD8+ 65 ± 91 150 ± 224 0.016
 cells CD4+ 106 ± 185 242 ± 320 0.001
 cells FoxP3+ 22 ± 40 44 ± 92 NS (0.08)
 cells CD20+ 134 ± 290 276 ± 504 NS
 cells CD38+ 28 ± 39 57 ± 73 0.024
 T/B ratio 7.2 [5.3–9.2] 11.0 [5.2–16.8] NS
 CD8+/FoxP3+ ratio 9.4 [5.1–13.7] 11.1 [5.2–15.9] NS
  1. Legend: Values given for individual lymphocyte subpopulations are mean ± SD; values for the ratios of lymphocyte counts are means and 95% CI Abbreviations: ER oestrogen receptor, PR progesterone receptor, NS not significant * = p value for the difference in global distribution of molecular subtypes between DCIS and miCa