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Fig. 5 | BMC Cancer

Fig. 5

From: Sequential decitabine and carboplatin treatment increases the DNA repair protein XPC, increases apoptosis and decreases proliferation in melanoma

Fig. 5

Combined decitabine and carboplatin decreases melanoma proliferation and can induce senescence. a Growth rate of melanoma cell lines treated with a control (DMEM), 0.26 μM decitabine, 8 μg/mL carboplatin or combined treatment. Data displayed is mean of triplicate experiments, error = SEM, significance compared between combined decitabine and carboplatin, and control, **p < 0.01. b Representative bright-field microscopy image of senescence associated β-galactosidase staining in all four melanoma cell lines after combined decitabine and carboplatin treatment. Arrows indicate regions of positive staining, bar = 100 μm

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