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Table 3 Common and rare sensitizing and not sensitizing mutations

From: Clinical management and outcome of patients with advanced NSCLC carrying EGFR mutations in Spain

Mutations (n = 168)a

n (%)

Sensitizing mutations

157 (93.4)

 Common

134 (79.8)

  Exon 19 (all mutations)

96 (57.1)

  Exon 21 L858R

38 (22.6)

 Rare

23 (13.7)

  Exon 18 G719X

10 (5.6)

  Exon 18 G719A

3 (1.8)

  Exon 18 G719S

3 (1.8)

  Exon 21 L861Q

7 (4.2)

Not sensitizing mutations

7 (4.2)

 Exon 20 (all mutations)

7 (4.2)

Mutations of unknown significance

4 (2.4)

 Exon 21 L858Q

1 (0.6)

 Exon 21 E829Q

1 (0.6)

 Exon 21 R836C

1 (0.6)

 Exon 21 T854S

1 (0.6)

  1. aMutation type not available for 1 patient with exon 18 and 11 patients with exon 11 mutations