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Table 2 Methods, source and type of tumor samples for EGFR mutation testing

From: Clinical management and outcome of patients with advanced NSCLC carrying EGFR mutations in Spain

Methods for EGFR mutation testing (n = 181)

n (%)

 Therascreen EGFR Mutation Test kit (ARMS) (Qiagen)

85 (47.0)

 RT-PCR (not specified)

26 (14.4)

 Fluorescent PCR fragment length analysis

22 (12.2)

 Direct sequencing

20 (11.0)

 Cobas EGFR Mutation Test kit (Roche)

9 (5.0)

 Allelic discrimination using fluorogenic probes

4 (2.2)

 Digital PCR

2 (1.1)

 Double PCR

1 (0.6)

 Non specified

16 (8.8)

Sample characteristics

n (%)

 Biopsy (n = 121)

123 (68.7)

  Tumor tissue source

   Primary tumor

94 (77.7)

   Metastatic sites

27 (22.3)

 Cytology (n = 55)

55 (30.7)

  Tumor tissue source

   Primary tumor

35 (63.6)

   Metastatic sites

20 (36.4)

 Biopsy and cytology type (n = 174)

  Bronchoscopy

74 (42.5)

  FNA

56 (32.2)

  Thoracocentesis

16 (9.2)

  Surgery

14 (8.0)

  Biopsy (unspecified)

8 (4.6)

  Videothoracoscopy

5 (2.9)

  Tru-cut

4 (2.3)

  EBUS

1 (0.6)

  Data not available

2 (1.1)

  1. EBUS Endobronchial ultrasound, FNA Fine-needle aspiration