Table 1 Patient characteristics (n=501)
Variable | Male | Female | P |
|---|---|---|---|
Median age, years | |||
Range | |||
 < 45 | 177(46.6%) | 75(62.0%) | 0.003 |
 ≥45 | 203(53.4%) | 46(38.0%) |  |
Marital status | |||
 Married | 17(4.5%) | 6(5.0%) | 0.833 |
 Single | 363(95.3%) | 115(95.0%) |  |
Education years | |||
 No formal education | 6(1.6%) | 7(5.8%) | 0.065 |
 Primary level | 49(12.9%) | 20(16.5%) |  |
 Secondary level | 99(26.1%) | 24(19.8%) |  |
 High school | 112(29.5%) | 37(30.6%) |  |
 University | 114(30.0%) | 33(27.3%) |  |
Smoking history | |||
 Ever | 159(41.8%) | 116(4.1%) | <0.0001 |
 Never | 221(58.2%) | 5(95.9%) |  |
Alcohol history | <0.0001 | ||
 Ever | 53(13.9%) | 0(0) |  |
 Never | 327(86.1%) | 121(100.0%) |  |
ECOG score | 0.174 | ||
 0 | 378(99.7%) | 118(99.2%) |  |
 1 | 0(0) | 1(0.8) |  |
 2 | 1(0.3%) | 0(0) |  |
WHO type | 0.862 | ||
 1 | 2(0.5%) | 1(0.8%) |  |
 2 | 2(0.5%) | 1(0.8%) |  |
 3 | 375(98.9%) | 117(98.3%) |  |
T stage | 0.521 | ||
 1 | 19(5.0%) | 3(2.5%) |  |
 2 | 67(17.6%) | 18(14.9%) |  |
 3 | 202(53.2%) | 71(58.7%) |  |
 4 | 92(24.2%) | 29(24.0%) |  |
N stage | 0.641 | ||
 0 | 50(13.2%) | 11(9.1%) |  |
 1 | 144(37.9%) | 51(42.1%) |  |
 2 | 146(38.4%) | 45(37.2%) |  |
 3 | 40(10.5%) | 14(11.6%) |  |
AJCC stage | 0.322 | ||
 1 | 7(1.8%) | 2(1.7%) |  |
 2 | 44(11.6%) | 7(5.8%) |  |
 3 | 207(54.5%) | 72(59.5%) |  |
 4 | 122(32.1%) | 40(33.1%) |  |
Treatment modality | |||
 RT | 27(7.1%) | 9(7.4%) |  |
 IC + CCRT | 194(51.1%) | 60(49.6%) |  |
 CCRT | 159(41.8%) | 52(43.0%) |  |
Median RT dose, Gy | |||
VCA IgA | 0.188 | ||
  < 1:80 | 151(39.7%) | 40(33.1%) |  |
  ≥ 1:80 | 229(60.3%) | 81(66.9%) |  |
EA IgA | 0.138 | ||
  < 1:10 | 199(52.4%) | 54(44.6%) |  |
  ≥ 1:10 | 181(47.6%) | 67(55.4%) |  |
Pre-EBV DNA | 0.526 | ||
  ≤ 4000 | 201 (52.9%) | 60(49.6%) |  |
  > 4000 | 179 (47.1%) | 61(50.4%) |  |
Post-EBV DNA | 0.780 | ||
 negative | 136(35.8%) | 45(37.2%) |  |
 positive | 244(64.2%) | 76(62.8%) |  |
Family history of NPC | 0.252 | ||
 yes | 18(4.7%) | 9(7.4%) |  |
 no | 362 (95.3%) | 112(92.6%) |  |