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Fig. 6 | BMC Cancer

Fig. 6

From: Testes-specific protease 50 (TSP50) promotes invasion and metastasis by inducing EMT in gastric cancer

Fig. 6

TSP50 induces EMT through NF-κB signaling pathway. a Expression levels of TSP50, E-Cadherin, Vimentin, Twist and nuclear p65 in MGC803 cell were determined by western blot analysis. β-actin and Histone1 were served as inner control of total protein and nuclear protein respectively. (*P < 0.05, **P < 0.01) (b)The positive association between TSP50 and p65 expression was showed in the same cohort of clinical gastric cancer tissue microarray using immunohistochemical staining. In panel high expression and low expression, the right panels displayed representative TSP50 and p65 proteins expression in selected zone with enlarged view. Scale bar = 100 μm. c Treatment with BAY117082 or transfection of shp65 reverted the effect of TSP50 on the migration and invasion in MGC803 cell partially. (*P < 0.05). All data are expressed as the mean ± SD from three independent experiments

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