Table 4 Clinicopathologic characteristics of eight patients with LRR in the patient cohort treated with endocrine therapy and no chemotherapy
Patients | #1 | #2 | #3 | #4 | #5 | #6 | #7 | #8 |
|---|---|---|---|---|---|---|---|---|
Family history of breast cancer | No | Yes | Yes | Yes | Yes | Yes | No | No |
BRCA mutations | Negative | Negative | Negative | Negative | Negative | Not tested | Not tested | Not tested |
Tumor histotype | IDC, Grade 2 | IDC, Grade 2 | IDC, Grade 1 | IDC, Grade 2 | ILC, not graded | IDC, Grade 1 | IDC, Grade 2 | IDC, Grade 2 |
Tumor size (cm) | 0.7 | 2.2 | 1.5 | 0.7 | 2.1 | 1.3 | 2 | 3.5 |
Multifocality | Yes | Yes | Yes | No | No | No | No | No |
LVI | No | No | No | Yes | No | No | Yes | Yes |
ER IHC (%) | 100 | 80 | 90 | 98 | 98 | 100 | 95 | 98 |
PR IHC (%) | 100 | 70 | 90 | 20 | 10 | 70 | 40 | 98 |
RS | 0 | 14 | 7 | 16 | 14 | 4 | 17 | 12 |
 ESR1 expression | 11.2 | 10.4 | 9.8 | 9.8 | 10.2 | 12.1 | 11.5 | 11.8 |
 PgR expression | >10 | 8.8 | 8.7 | 5.8 | 6.6 | 9.1 | 6.3 | >10 |
Surgery | TM | TM | TM | BCS | BCS | BCS | BCS | BCS |
Radiation therapy | No | No | No | Yes | Yes | No | Yes | No |
Time to LRR (months) | 42 | 65 | 29 | 50 | 37 | 41 | 24 | 46 |
Site of LRR | Chest wall | Internal mammary node | Chest wall | Ipsilateral breast | Ipsilateral breast | Ipsilateral breast | Ipsilateral breast | Ipsilateral breast |