Fig. 5
From: Optimising the chick chorioallantoic membrane xenograft model of neuroblastoma for drug delivery
ATRA promotes the differentiation of tumours without affecting chick embryo survival. a. qPCR analysis of changes in relative target gene expression following daily treatment of 100 μM ATRA at E11, 12 and 13. Each bar in the graph represents the mean of three biological repeats. ROBO2 and STMN4 show statistical significant changes for BE(2)C and KLF4 and STMN4 show significant changes for IMR32. *p < 0.05. Error bars are SE. b. Neither DMSO (28 μl injections X3) nor ATRA (100 μM injections X3) affected the survival of the chick embryos (n > 30 for all conditions)