Fig. 7

Observed mutant frequencies of late mutations. Observed mutant frequencies were computed by dividing the number of mutant read counts by the number of total read counts. a Mutaant frequency distribution where all late mutations were pooled together. b Histogram for one region with the largest number of late driver mutations (163 mutations). The data are from region rec52 from the patient 1402 [25]. c Regional average mutant frequencies of late drivers and late passengers for all Regions with at least 10 late driver mutations. Patient IDs are presented along x-axis, and region IDs are shown within parentheses. The differences of mutant frequencies between driver and passenger were not statistically significant in any region (P > 0.05; t-test). Also, the results of all late mutations pooled from all regions are shown (All; P = 0.01 by t-test, while the difference was only 1%). Error bars are standard errors. Driver and passenger mutations are shown with red and gray bars, respectively