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Fig. 2 | BMC Cancer

Fig. 2

From: Somatic evolutionary timings of driver mutations

Fig. 2

Fraction of driver mutations occurring at early and late time. Driver mutations were annotated as those found in cancer-associated genes. a Fraction of all driver mutations that occurred early and late as inferred from multi-sample profiles. Each dot refers to data from one patient from a study, and a bar shows the average. Statistical tests (paired t-test) were performed to test if the fraction of early-driver mutations is significantly different from late-driver mutations for a cancer type. Cancer types that have significantly different fractions (P ≤ 0.05) are shown with asterisks. b The difference in early and late driver mutation fractions for individual patients. Zero difference was found for 15 patients. Three data sets were removed because there were zero driver mutations after removing variants absent from all tumors after the application of Treeomics software (see Methods)

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