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Table 2 Hazard ratios (HRs) of mortality, and corresponding 95% confidence intervals (CIs), according to selected clinical and pathological characteristics, among 841 triple-negative breast cancers (TNBCs). Sardinia, Italy 1994–2015

From: Clinical and pathological factors influencing survival in a large cohort of triple-negative breast cancer patients

  

Number of deaths (%)

HRa (95% CI)

HRb (95% CI)

Tumor histotype

 Ductal invasive carcinoma

625

106 (16.9)

1.00c

1.00c

 Lobular carcinoma

65

14 (21.2)

1.04 (0.59–1.84)

0.66 (0.31–1.42)

 Other carcinomasd

104

12 (11.9)

0.56 (0.30–1.02)

0.40 (0.21–0.76)

Histologic grade

 1,2

180

40 (22.2)

1.00c

1.00c

 3

600

102 (17.0)

1.12 (0.77–1.63)

0.96 (0.58–1.58)

Tumor size (T)

 T1

309

30 (9.7)

1.00c

1.00c

 T2

364

67 (18.4)

2.71 (1.74–4.23)

2.41 (1.40–4.15)

 T3

55

13 (23.6)

2.85 (1.46–5.55)

2.24 (1.00–5.06)

 T4

43

17 (39.5)

8.13 (4.44–14.9)

5.13 (2.21–11.9)

Pathological lymph nodes (pN)

 pN0

439

39 (8.9)

1.00c

1.00c

 pN1

185

42 (22.7)

2.63 (1.69–4.10)

2.04 (1.22–3.40)

 pN2

88

21 (23.9)

3.54 (2.06–6.06)

3.11 (1.70–5.68)

 pN3

46

19 (41.3)

6.10 (3.44–10.8)

3.18 (1.51–6.71)

Distant metastases (M)

 M0

747

117 (15.7)

1.00c

1.00c

 M1

10

7 (70.0)

6.01 (2.72–13.3)

5.13 (1.69–15.6)

Tumor stagee

 I

211

11 (5.2)

1.00c

1.00c

 II

359

48 (13.4)

3.09 (1.59–6.00)

3.13 (1.56–6.27)

 III

161

52 (32.3)

9.68 (5.02–18.7)

9.65 (4.66–20.0)

 IV

10

7 (70.0)

19.8 (7.54–51.9)

29.0 (9.65–86.9)

Tumor infiltrating lymphocytes (TIL)

 No

497

90 (18.1)

1.00c

1.00c

 Yes

283

40 (14.1)

1.24 (0.85–1.80)

1.20 (0.76–1.91)

Lymphovascular invasion (LVI)

 No

587

82 (14.0)

1.00c

1.00c

 Yes

193

48 (24.9)

2.45 (1.71–3.51)

1.49 (0.93–2.38)

Necrosis

 No

480

71 (14.8)

1.00c

1.00c

 Yes

301

60 (19.9)

1.58 (1.11–2.24)

1.61 (1.03–2.51)

Ki-67 (%)

 0–15

112

19 (17.0)

1.00c

1.00c

 16–25

95

31 (32.6)

2.15 (1.21–3.83)

2.19 (1.03–4.66)

 26–35

122

24 (19.7)

1.45 (0.79–2.65)

1.65 (0.71–3.84)

 36–45

100

18 (18.0)

1.46 (0.76–2.80)

1.69 (0.70–4.09)

  ≥ 46

376

57 (15.2)

2.00 (1.14–3.51)

2.37 (1.08–5.21)

  1. aEstimates from multivariate proportional hazard regression models adjusted for study center and age at diagnosis. Estimates in bold are those significant at the 0.05 level. bEstimates further adjusted for TNM-T, TNM-N, TNM-M, necrosis, LVI, and Ki-67. cReference category. dIncluding medullary, apocrine, pleomorphic, and metaplastic carcinomas. eEstimates not adjusted for TNM-T, TNM-N, and TNM-M