Number of deaths (%) | HRa (95% CI) | HRb (95% CI) | ||
---|---|---|---|---|
Tumor histotype | ||||
Ductal invasive carcinoma | 625 | 106 (16.9) | 1.00c | 1.00c |
Lobular carcinoma | 65 | 14 (21.2) | 1.04 (0.59–1.84) | 0.66 (0.31–1.42) |
Other carcinomasd | 104 | 12 (11.9) | 0.56 (0.30–1.02) | 0.40 (0.21–0.76) |
Histologic grade | ||||
1,2 | 180 | 40 (22.2) | 1.00c | 1.00c |
3 | 600 | 102 (17.0) | 1.12 (0.77–1.63) | 0.96 (0.58–1.58) |
Tumor size (T) | ||||
T1 | 309 | 30 (9.7) | 1.00c | 1.00c |
T2 | 364 | 67 (18.4) | 2.71 (1.74–4.23) | 2.41 (1.40–4.15) |
T3 | 55 | 13 (23.6) | 2.85 (1.46–5.55) | 2.24 (1.00–5.06) |
T4 | 43 | 17 (39.5) | 8.13 (4.44–14.9) | 5.13 (2.21–11.9) |
Pathological lymph nodes (pN) | ||||
pN0 | 439 | 39 (8.9) | 1.00c | 1.00c |
pN1 | 185 | 42 (22.7) | 2.63 (1.69–4.10) | 2.04 (1.22–3.40) |
pN2 | 88 | 21 (23.9) | 3.54 (2.06–6.06) | 3.11 (1.70–5.68) |
pN3 | 46 | 19 (41.3) | 6.10 (3.44–10.8) | 3.18 (1.51–6.71) |
Distant metastases (M) | ||||
M0 | 747 | 117 (15.7) | 1.00c | 1.00c |
M1 | 10 | 7 (70.0) | 6.01 (2.72–13.3) | 5.13 (1.69–15.6) |
Tumor stagee | ||||
I | 211 | 11 (5.2) | 1.00c | 1.00c |
II | 359 | 48 (13.4) | 3.09 (1.59–6.00) | 3.13 (1.56–6.27) |
III | 161 | 52 (32.3) | 9.68 (5.02–18.7) | 9.65 (4.66–20.0) |
IV | 10 | 7 (70.0) | 19.8 (7.54–51.9) | 29.0 (9.65–86.9) |
Tumor infiltrating lymphocytes (TIL) | ||||
No | 497 | 90 (18.1) | 1.00c | 1.00c |
Yes | 283 | 40 (14.1) | 1.24 (0.85–1.80) | 1.20 (0.76–1.91) |
Lymphovascular invasion (LVI) | ||||
No | 587 | 82 (14.0) | 1.00c | 1.00c |
Yes | 193 | 48 (24.9) | 2.45 (1.71–3.51) | 1.49 (0.93–2.38) |
Necrosis | ||||
No | 480 | 71 (14.8) | 1.00c | 1.00c |
Yes | 301 | 60 (19.9) | 1.58 (1.11–2.24) | 1.61 (1.03–2.51) |
Ki-67 (%) | ||||
0–15 | 112 | 19 (17.0) | 1.00c | 1.00c |
16–25 | 95 | 31 (32.6) | 2.15 (1.21–3.83) | 2.19 (1.03–4.66) |
26–35 | 122 | 24 (19.7) | 1.45 (0.79–2.65) | 1.65 (0.71–3.84) |
36–45 | 100 | 18 (18.0) | 1.46 (0.76–2.80) | 1.69 (0.70–4.09) |
≥ 46 | 376 | 57 (15.2) | 2.00 (1.14–3.51) | 2.37 (1.08–5.21) |