Table 1 Characteristics of 841 triple-negative breast cancer (TNBC) patients. Sardinia, Italy 1994–2015
TNBC patients | ||
|---|---|---|
N | % | |
Calendar period at diagnosis | ||
1994–2004 | 289 | 34.4 |
2005–2009 | 294 | 34.9 |
2010–2015 | 258 | 30.1 |
Age at diagnosis (years) | ||
< 45 | 190 | 22.6 |
45–54 | 201 | 23.9 |
55–64 | 226 | 26.9 |
≥ 65 | 224 | 26.6 |
Age at menarche (years) | ||
< 12 | 106 | 12.6 |
12 | 166 | 19.7 |
13 | 190 | 22.6 |
≥ 14 | 193 | 23.0 |
Missing | 186 | 22.1 |
Parity | ||
Parous | 567 | 67.4 |
Nulliparous | 117 | 13.9 |
Missing | 157 | 18.7 |
Menopausal status | ||
Pre-menopause | 255 | 30.3 |
Post-menopause | 501 | 59.6 |
Missing | 85 | 10.1 |
Tumor histotype | ||
Invasive ductal carcinoma | 625 | 74.3 |
Lobular carcinoma | 65 | 7.7 |
Medullary carcinoma | 29 | 3.4 |
Apocrine carcinoma | 20 | 2.4 |
Pleomorphic carcinoma | 14 | 1.7 |
Metaplastic carcinoma | 12 | 1.4 |
Others | 29 | 3.4 |
Missing | 47 | 5.6 |
Histologic grade | ||
1 | 11 | 1.3 |
2 | 169 | 20.1 |
3 | 600 | 71.3 |
Missing | 61 | 7.3 |
Tumor size (T) | ||
Tx | 15 | 1.8 |
T1 | 309 | 36.7 |
T2 | 364 | 43.3 |
T3 | 55 | 6.5 |
T4 | 43 | 5.1 |
Missing | 55 | 6.5 |
Pathological lymph nodes (pN) | ||
pNx | 26 | 3.1 |
pN0 | 439 | 52.2 |
pN1 | 185 | 22.0 |
pN2 | 88 | 10.5 |
pN3 | 46 | 5.6 |
Missing | 57 | 6.8 |
Distant metastases (M) | ||
M0 | 747 | 88.8 |
M1 | 10 | 1.2 |
Missing | 84 | 10.0 |
Tumor stage | ||
I | 211 | 25.1 |
II | 359 | 42.7 |
III | 161 | 19.1 |
IV | 10 | 1.2 |
Missing | 100 | 11.9 |
Tumor infiltrating lymphocytes | ||
No | 497 | 59.1 |
Yes | 283 | 33.7 |
Missing | 61 | 7.2 |
Lymphovascular invasion | ||
No | 587 | 69.8 |
Yes | 193 | 23.0 |
Missing | 61 | 7.2 |
Necrosis | ||
No | 480 | 57.1 |
Yes | 301 | 35.8 |
Missing | 60 | 7.1 |
Ki-67 (%) | ||
0–15 | 112 | 13.3 |
16–25 | 95 | 11.3 |
26–35 | 122 | 14.5 |
36–45 | 100 | 11.9 |
≥ 46 | 376 | 44.7 |
Missing | 36 | 4.3 |
Type of surgery | ||
No surgery | 6 | 0.7 |
Quadrantectomy | 437 | 52.0 |
Mastectomy | 319 | 37.9 |
Missing | 79 | 9.4 |
Radiotherapy on residual breasta | ||
No | 0 | 0.0 |
Yes | 411 | 94.1 |
Missing | 26 | 5.9 |
Post-mastectomy radiotherapyb | ||
No | 236 | 74.0 |
Yes | 24 | 7.5 |
Missing | 59 | 18.5 |
Chemotherapy | ||
Neoadjuvant, only | 34 | 4.0 |
Adjuvant, only | 545 | 64.8 |
Neoadjuvant and adjuvant | 73 | 8.7 |
Missing | 189 | 22.5 |