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Table 1 Characteristics of 841 triple-negative breast cancer (TNBC) patients. Sardinia, Italy 1994–2015

From: Clinical and pathological factors influencing survival in a large cohort of triple-negative breast cancer patients

  TNBC patients
N %
Calendar period at diagnosis
 1994–2004 289 34.4
 2005–2009 294 34.9
 2010–2015 258 30.1
Age at diagnosis (years)
  < 45 190 22.6
 45–54 201 23.9
 55–64 226 26.9
  ≥ 65 224 26.6
Age at menarche (years)
  < 12 106 12.6
 12 166 19.7
 13 190 22.6
  ≥ 14 193 23.0
Missing 186 22.1
Parity
 Parous 567 67.4
 Nulliparous 117 13.9
Missing 157 18.7
Menopausal status
 Pre-menopause 255 30.3
 Post-menopause 501 59.6
Missing 85 10.1
Tumor histotype
 Invasive ductal carcinoma 625 74.3
 Lobular carcinoma 65 7.7
 Medullary carcinoma 29 3.4
 Apocrine carcinoma 20 2.4
 Pleomorphic carcinoma 14 1.7
 Metaplastic carcinoma 12 1.4
 Others 29 3.4
Missing 47 5.6
Histologic grade
 1 11 1.3
 2 169 20.1
 3 600 71.3
Missing 61 7.3
Tumor size (T)
 Tx 15 1.8
 T1 309 36.7
 T2 364 43.3
 T3 55 6.5
 T4 43 5.1
Missing 55 6.5
Pathological lymph nodes (pN)
 pNx 26 3.1
 pN0 439 52.2
 pN1 185 22.0
 pN2 88 10.5
 pN3 46 5.6
Missing 57 6.8
Distant metastases (M)
 M0 747 88.8
 M1 10 1.2
Missing 84 10.0
Tumor stage
 I 211 25.1
 II 359 42.7
 III 161 19.1
 IV 10 1.2
Missing 100 11.9
Tumor infiltrating lymphocytes
 No 497 59.1
 Yes 283 33.7
Missing 61 7.2
Lymphovascular invasion
 No 587 69.8
 Yes 193 23.0
Missing 61 7.2
Necrosis
 No 480 57.1
 Yes 301 35.8
Missing 60 7.1
Ki-67 (%)
 0–15 112 13.3
 16–25 95 11.3
 26–35 122 14.5
 36–45 100 11.9
  ≥ 46 376 44.7
Missing 36 4.3
Type of surgery
 No surgery 6 0.7
 Quadrantectomy 437 52.0
 Mastectomy 319 37.9
Missing 79 9.4
Radiotherapy on residual breasta
 No 0 0.0
 Yes 411 94.1
Missing 26 5.9
Post-mastectomy radiotherapyb
 No 236 74.0
 Yes 24 7.5
Missing 59 18.5
Chemotherapy
 Neoadjuvant, only 34 4.0
 Adjuvant, only 545 64.8
 Neoadjuvant and adjuvant 73 8.7
Missing 189 22.5
  1. aFor patients who had a quadrantectomy. bFor patients who had a mastectomy
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