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Table 2 Bayesian latent class estimates of sensitivity and specificity of E-cadherin measurements in colorectal primary tumor cancer cells to assess cancer cell detachment from primary tumor (n = 188)

From: Diagnostic accuracy and prediction increment of markers of epithelial-mesenchymal transition to assess cancer cell detachment from primary tumors

  Fully Fully Partial Dependent Models
  Independent Dependent PDM 1 PDM 2 PDM 3 PDM 4 PDM 5 PDM 6
Constraints Set to 0 All None Se(Ecad) Se(LN) Se(RI) Se(Ecad) Se(Ecad) Se(LN)
    Sp(Ecad) Sp(LN) Sp(RI) Sp(Ecad) Sp(Ecad) Sp(LN)
       Se(LN) Se(RI) Se(RI)
       Sp(LN) Sp(RI) Sp(RI)
E-cadherin Variable Se Sp Se Sp Se Sp Se Sp Se Sp Se Sp Se Sp Se Sp
Dichotomized at 0.52 47 28 54 44 52 49 52 42 53 44 47 28 52 48 52 43
Dichotomized at 0.60 49 22 57 43 53 40 53 41 53 43 49 22 53 40 52 42
Dichotomized at 0.85 46 14 53 43 52 41 52 42 53 43 46 14 52 41 52 41
  1. Cellular membrane E-cadherin expression measured as protein in primary tumor cancer cells on a continuous average intensity scale (0–3), then dichotomized at the indicated cut point (coded EMT positive versus EMT negative). LN and RI were each coded as dichotomous positive versus negative. LN and RI each assigned the same prior of Se 60–70% and Sp 95–99%. For all dichotomous test variables, positive results mean evidence supporting detachment of cancer cells from the primary tumor and negative results mean no evidence of detachment. All Se and Sp estimates are reported as percentages
  2. Ecad E-cadherin, LN lymph node evaluation, PDM partial dependent model, RI radiologic imaging, Se sensitivity, Sp specificity