Diagnostic accuracy and prediction increment of markers of epithelial-mesenchymal transition to assess cancer cell detachment from primary tumors

Table 1 Subject characteristics (n = 188)

	Mean	SD
Age (years)	67	13
	N	%
Sex
Male	89	47
Female	99	53
Race
Non-Hispanic White	149	79
Hispanic or non-White	39	21
Tumor Stage
Local (I or II)	99	53
Regional (III)	66	35
Distant (IV)	23	12
Lymph Node Diagnostic Status^a
Positive	86	46
Negative	102	54
Radiologic Imaging Diagnostic Status^a
Positive	23	12
Negative	165	88
EMT Diagnostic Status, Cut Point = 0.52^b
Positive	11	6
Negative	177	94
EMT Diagnostic Status, Cut Point = 0.60^b
Positive	28	15
Negative	160	85
EMT Diagnostic Status, Cut Point = 0.85^b
Positive	108	57
Negative	80	43

^aInferred from tumor stage. See Methods section for assignment rules
^bBased on E-cadherin expression in primary tumor cancer cells measured as a weighted average of tumor cores on a continuous average intensity scale of 0–3. Low E-cadherin expression (below the cut point) is evidence of EMT (EMT-positive)
EMT Epithelial-mesenchymal transition

ISSN: 1471-2407