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Fig. 4 | BMC Cancer

Fig. 4

From: Regulation of pancreatic stellate cell activation by Notch3

Fig. 4

Effect of siRNA-mediated Notch3 inhibition on mouse PaSC activation. a Transfection of Notch 3 siRNA in mouse PaSCs activation after 48 h, the morphological changes in PaSCs. b Representative western blotting images showing the effect of siRNA-mediated Notch3 inhibition on PaSC activation markers, such as α-SMA, fibronectin and collagen I, and on the Notch target gene HES1; densitometry analyses of the blots are also shown. c RT-qPCR results showing the effect of siRNA-mediated Notch3 inhibition on PaSC activation markers, such as α-SMA, fibronectin and collagen I, and on the Notch target gene HES1 at the transcriptional level. Scale bars: 100 μm in (a). The data are presented as the mean ± SD, *P < 0.05, **P < 0.01, and ***P < 0.001; n = 4; Student’s t-test

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