Table 1 The half-maximal inhibition (IC50) and area under the curve (AUC) values for MDA-MB-231 and MCF-7 cells cultured in 2D and 3D cell culture
From: Doxorubicin resistance in breast cancer cells is mediated by extracellular matrix proteins
| Doxorubicin | MDA-MB-231 | MCF-7 | ||
|---|---|---|---|---|
| 2D | 3D | 2D | 3D | |
| Drug IC50 (nM) | 87.7 ± 10.6 | 636.0 ± 160.3*** | 225.2 ± 64.2 | 10,000#**** |
| AUC (units) | 370.4 ± 17.1 | 244.7 ± 13.7**** | 291.4 ± 7.8 | 174.4 ± 9.1**** |
