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Table 1 The half-maximal inhibition (IC50) and area under the curve (AUC) values for MDA-MB-231 and MCF-7 cells cultured in 2D and 3D cell culture

From: Doxorubicin resistance in breast cancer cells is mediated by extracellular matrix proteins

Doxorubicin MDA-MB-231 MCF-7
2D 3D 2D 3D
Drug IC50 (nM) 87.7 ± 10.6 636.0 ± 160.3*** 225.2 ± 64.2 10,000#****
AUC (units) 370.4 ± 17.1 244.7 ± 13.7**** 291.4 ± 7.8 174.4 ± 9.1****
  1. Significance values are: p ≤ 0.001 (***), p ≤ 0.0001 (****).#GraphPad Prism unable to calculate IC50 value, estimated from raw data. Data represent mean ± standard deviation, n = 3