Fig. 5
From: Doxorubicin resistance in breast cancer cells is mediated by extracellular matrix proteins
Modulation of pro-survival proteins in 2D and 3D cell culture. Bcl-xL (a) and Bcl-2 (b) protein expression in MDA-MB-231 monolayer cultured cells over time following exposure to doxorubicin. Bcl-xL (c) and Bcl-2 (d) protein expression in MDA-MB-231 cells in 3D culture conditions over time following exposure to doxorubicin. Arrows indicate nuclear localisation of Bcl-2. Significance values are: p ≤ 0.01 (**), p ≤ 0.0001 (****). Scale bar = 50 μm. Data represent mean ± standard error