Patient characteristics | All patients (n = 304) | Del-19 (n = 36) | L858R (n = 42) | p-value (Del-19/L858R) | Wild type (n = 226) | |||
---|---|---|---|---|---|---|---|---|
No. of patients | % | No. of patients | % | No. of patients | % | |||
Age (years) | ||||||||
 Median (range) | 64.0 (37–78) | 62.5 (41–77) | 66.0 (38–78) |  | 64.0 (37–78) | |||
  < 65 | 160 | 20 | 55.6 | 17 | 40.5 | 0.18 | 123 | 54.4 |
  ≥ 65 | 144 | 16 | 44.4 | 25 | 59.5 |  | 103 | 45.6 |
Gender | ||||||||
 Male | 216 | 19 | 52.8 | 15 | 35.7 | 0.13 | 182 | 80.5 |
 Female | 88 | 17 | 47.2 | 27 | 64.3 |  | 44 | 19.5 |
PS (ECOG) | ||||||||
 0–1 | 273 | 35 | 97.2 | 40 | 95.2 | 0.65 | 198 | 87.6 |
 2 | 31 | 1 | 2.8 | 2 | 4.8 |  | 28 | 12.4 |
Smoking history | ||||||||
 Never | 85 | 20 | 55.6 | 30 | 71.4 | 0.15 | 35 | 15.5 |
 Ever | 219 | 16 | 44.4 | 12 | 28.6 |  | 191 | 84.5 |
Clinical stage | ||||||||
 IIIB, IV | 277 | 30 | 83.3 | 35 | 83.3 | 1.00 | 212 | 93.8 |
 Recurrence | 27 | 6 | 16.7 | 7 | 16.7 |  | 14 | 6.2 |
Histology | ||||||||
 Adenocarcinoma | 276 | 34 | 94.4 | 42 | 100 | 0.30 | 200 | 88.5 |
 Large cell carcinoma | 4 | 1 | 2.8 | 0 | 0 |  | 3 | 1.3 |
 NSCLC-NOS | 24 | 1 | 2.8 | 0 | 0 |  | 23 | 10.2 |
Induction therapy cycles | ||||||||
 Mean (range) | 3.7(1–6) | 3.7 (1–6) | 4.0 (1–6) | 0.23 | 3.6 (1–6) | |||
Maintenance therapy cycles | ||||||||
 Mean (range) | 3.3(0–30) | 4.1 (0–30) | 6.0 (0–22) | 0.17 | 2.7 (0–30) |