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Table 4 Associations of fold change in gene expression with prognostic factors in differentiated thyroid cancer

From: CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and predict extrathyroidal extension

   Age (≥ 45 years) Tumour size (> 4 cm) Extrathyroidal extension
  Expression level (fold change) Univariate analysis   Univariate analysis   Univariate analysis Multivariate analysis
   OR (95% CI) P value OR (95% CI) P value OR (95% CI) P value OR (95% CI) P value
C1QL1 Gain (>1) 2.02 (0.835–4.88) NS (0.119) 4.60 (0.963–21.9) NS (0.056) 5.34 (1.63–17.5) 0.006 4.86 (1.43–16.5) 0.011
LCN2 Gain (>1) 1.17 (0.484–2.83) NS (0.726) 0.730 (0.209–2.55) NS (0.622) 3.48 (1.14–10.6) 0.029 3.39 (1.06–10.9) 0.039
CRABP1 Loss (<−1) 0.622 (0.197–1.97) NS (0.419) 1.345 (0.268–6.75) NS (0.719) 1.74 (0.436–6.96) NS (0.432)
CILP Loss (<−1) 0.481 (0.201–1.15) NS (0.100) 2.75 (0.705–10.7) NS (0.145) 1.40 (0.530–3.70) NS (0.496)
  1. Bold values indicate the result was statistically significant