Table 4 Associations of fold change in gene expression with prognostic factors in differentiated thyroid cancer
Age (≥ 45 years) | Tumour size (> 4 cm) | Extrathyroidal extension | |||||||
|---|---|---|---|---|---|---|---|---|---|
Expression level (fold change) | Univariate analysis | Univariate analysis | Univariate analysis | Multivariate analysis | |||||
OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | ||
C1QL1 | Gain (>1) | 2.02 (0.835–4.88) | NS (0.119) | 4.60 (0.963–21.9) | NS (0.056) | 5.34 (1.63–17.5) | 0.006 | 4.86 (1.43–16.5) | 0.011 |
LCN2 | Gain (>1) | 1.17 (0.484–2.83) | NS (0.726) | 0.730 (0.209–2.55) | NS (0.622) | 3.48 (1.14–10.6) | 0.029 | 3.39 (1.06–10.9) | 0.039 |
CRABP1 | Loss (<−1) | 0.622 (0.197–1.97) | NS (0.419) | 1.345 (0.268–6.75) | NS (0.719) | 1.74 (0.436–6.96) | NS (0.432) | – | – |
CILP | Loss (<−1) | 0.481 (0.201–1.15) | NS (0.100) | 2.75 (0.705–10.7) | NS (0.145) | 1.40 (0.530–3.70) | NS (0.496) | – | – |