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Table 2 Diagnostic performance of potential biomarkers for differentiated thyroid cancer (DTC)

From: CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and predict extrathyroidal extension

Biomarker

Cut-off

Sensitivity (%)

Specificity (%)

  

DTC

DTC vs normal thyroid

DTC vs FTA

C1QL1

>1

62.9 (52.0–72.9)

82.4 (56.6–96.0)

58.8 (33.0–81.5)

LCN2

>1

64.0 (52.9–74.0)

73.3 (44.9–92.1)

83.3 (58.6–96.2)

CRABP1

<−1

84.3 (75.0–91.1)

88.9 (65.3–98.3)

35.7 (12.9–64.8)

CILP

<−1

61.4 (50.4–71.6)

66.7 (35.0–89.9)

53.0 (27.9–77.0)

  1. Sensitivities and specificities are indicated comparing DTC with normal thyroid tissue or follicular thyroid adenoma (FTA)