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Table 2 Diagnostic performance of potential biomarkers for differentiated thyroid cancer (DTC)

From: CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and predict extrathyroidal extension

Biomarker Cut-off Sensitivity (%) Specificity (%)
   DTC DTC vs normal thyroid DTC vs FTA
C1QL1 >1 62.9 (52.0–72.9) 82.4 (56.6–96.0) 58.8 (33.0–81.5)
LCN2 >1 64.0 (52.9–74.0) 73.3 (44.9–92.1) 83.3 (58.6–96.2)
CRABP1 <−1 84.3 (75.0–91.1) 88.9 (65.3–98.3) 35.7 (12.9–64.8)
CILP <−1 61.4 (50.4–71.6) 66.7 (35.0–89.9) 53.0 (27.9–77.0)
  1. Sensitivities and specificities are indicated comparing DTC with normal thyroid tissue or follicular thyroid adenoma (FTA)