MLH1–93 G/a polymorphism is associated with MLH1 promoter methylation and protein loss in dysplastic sessile serrated adenomas with BRAFV600E mutation

Table 2 MLH1–93 single nucleotide polymorphism genotypes in controls, sessile serrated adenomas with dysplasia, traditional serrated adenomas and BRAF mutant cancers

	Mismatch Repair Status	Total n	GG n (%)	P-Value^*	GA n (%)	P-Value^*	AA n (%)	P-Value^*
Controls		147	87 (59%)		53 (36%)		7 (5%)
SSAD	Deficient	94	44 (47%)	0.036	37 (39%)	0.393	13 (14%)	0.037
	Proficient	30	21 (70%)	0.036	9 (30%)	0.393	0	0.037
TSA	Deficient	1	0		1		0
	Proficient	127	76 (60%)		45 (35%)		6 (5%)
Cancer	Deficient	116	52 (44.8%)	0.011	51 (43.9%)	0.194	13 (11.2%)	0.015
	Proficient	87	55 (63.2%)	0.011	30 (34.5%)	0.194	2 (2.3%)	0.015

ISSN: 1471-2407