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Table 1 Statistically significant hits from NGS of examined NMSC patients (n = 33)

From: Coordinated expression and genetic polymorphisms in Grainyhead-like genes in human non-melanoma skin cancers

Chr: Gene dbSNP ID location allele AF_OBS AF_EUR
(1000G)
p-value* OR, (95%CI), p-value**
Chr1: GRHL3 rs55927162
intergenic
(dist = 4635)***
T/A 0.6667 0.21 P < 0.00001
2)
(A) OR = 7.53
(95%CI:4.38–12.94)
P < 0.0001
rs56256719
intergenic
(dist = 4627)***
T/A 0.697 0.24 P < 0.00001
2)
(A) OR = 7.15
(95%CI:4.14–12.44)
P < 0.0001
rs151171718
intronic
A/T 0.0455 0.0013 P < 0.05
(F)
(T) OR = 36.05
(95%CI:3.69–351.64)
P = 0.0020
rs141193530
exon 11 (P455A)
C/G 0.0758 0.004 P < 0.00001
2)
(G) OR = 20.63
(95%CI:4.81–88.38)
P < 0.0001
rs151326764
exon 16 (R573H)
G/A 0.0303 0.0026 P < 0.01
(F)
(A) OR = 11.81
(95%CI:1.63–85.26)
P = 0.0143
Chr8: GRHL2 rs548650
intronic
G/A 0.0909 0.02 P = 0.000039
2)
(A) OR = 5.73
(95%CI:2.10–15.62)
P = 0.0006
  1. AF_OBS observed allele frequency, AF_EUR expected allele frequency for general European population (1000Genomes)
  2. *p-value of association calculated with χ2-test (χ2) or Fisher’s exact test (F) for less frequent alleles
  3. **OR odds ratio for haplotype, 95%CI 95% confidence interval, calculated according to [25]
  4. ***distance upstream from transcription start site