From: Colorectal cancer liver metastases – a population-based study on incidence, management and survival
Univariate analysis | Multivariate analysis | |||
---|---|---|---|---|
Hazard ratio | P | Hazard ratio | P | |
Age (years)a | 1.03 (1.02–1.05) | <0.001 | 1.03 (1.01–1.05) | 0.002 |
Sex | ||||
Female | 1.00 (reference) | 1.00 (reference) | ||
Male | 0.80 (0.62–1.04) | 0.099 | 0.91 (0.65–1.28) | 0.598 |
Tumour stageb | ||||
T1-T2 | 1.00 (reference) | |||
T3-T4 | 1.03 (0.56–1.89) | 0.929 | ||
Nodal stagec | ||||
N0 | 1.00 (reference) | 1.00 (reference) | ||
N1-N2 | 1.65 (1.10–2.46) | 0.014 | 0.89 (0.57–1.37) | 0.586 |
Primary tumour origin | ||||
Right-sided | 1.00 (reference) | 1.00 (reference) | ||
Left-sidedd | 0.51 (0.39–0.68) | <0.001 | 0.56 (0.39–0.79) | 0.001 |
Time of detection of liver metastases | ||||
Metachronous | 1.00 (reference) | 1.00 (reference) | ||
Synchronous | 1.49 (1.14–1.94) | 0.004 | 0.91(0.64–1.30) | 0.606 |
Size of largest liver metastasis (mm) | ||||
< 50 mm | 1.00 (reference) | 1.00 (reference) | ||
> 50 mm | 3.07 (2.34–4.03) | <0.001 | 2.51 (1.73–3.65) | <0.001 |
Number of liver metastases | ||||
1–2 | 1.00 (reference) | 1.00 (reference) | ||
3–4 | 1.06 (0.67–1.68) | 0.800 | 1.06 (0.60–1.89) | 0.836 |
≥ 5 | 2.83 (2.12–3.77) | 0.000 | 1.41 (0.94–2.11) | 0.095 |
Liver resection | ||||
No | 1.00 (reference) | 1.00 (reference) | ||
Yes | 0.14 (0.10–0.21) | <0.001 | 0.21 (0.13–0.33) | <0.001 |
Lung metastases | ||||
No | 1.00 (reference) | 1.00 (reference) | ||
Yes | 1.26 (0.98–1.64) | 0.073 | 1.11 (0.80–1.53) | 0.528 |