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Table 5 Univariate and multivariate Cox regression analysis of factors influencing OS in patients with CRCLM

From: Colorectal cancer liver metastases – a population-based study on incidence, management and survival

 

Univariate analysis

Multivariate analysis

Hazard ratio

P

Hazard ratio

P

Age (years)a

1.03 (1.02–1.05)

<0.001

1.03 (1.01–1.05)

0.002

Sex

 Female

1.00 (reference)

 

1.00 (reference)

 

 Male

0.80 (0.62–1.04)

0.099

0.91 (0.65–1.28)

0.598

Tumour stageb

 T1-T2

1.00 (reference)

   

 T3-T4

1.03 (0.56–1.89)

0.929

Nodal stagec

 N0

1.00 (reference)

 

1.00 (reference)

 

 N1-N2

1.65 (1.10–2.46)

0.014

0.89 (0.57–1.37)

0.586

Primary tumour origin

 Right-sided

1.00 (reference)

 

1.00 (reference)

 

 Left-sidedd

0.51 (0.39–0.68)

<0.001

0.56 (0.39–0.79)

0.001

Time of detection of liver metastases

 Metachronous

1.00 (reference)

 

1.00 (reference)

 

 Synchronous

1.49 (1.14–1.94)

0.004

0.91(0.64–1.30)

0.606

Size of largest liver metastasis (mm)

 < 50 mm

1.00 (reference)

 

1.00 (reference)

 

 > 50 mm

3.07 (2.34–4.03)

<0.001

2.51 (1.73–3.65)

<0.001

Number of liver metastases

 1–2

1.00 (reference)

 

1.00 (reference)

 

 3–4

1.06 (0.67–1.68)

0.800

1.06 (0.60–1.89)

0.836

  ≥ 5

2.83 (2.12–3.77)

0.000

1.41 (0.94–2.11)

0.095

Liver resection

 No

1.00 (reference)

 

1.00 (reference)

 

 Yes

0.14 (0.10–0.21)

<0.001

0.21 (0.13–0.33)

<0.001

Lung metastases

 No

1.00 (reference)

 

1.00 (reference)

 

 Yes

1.26 (0.98–1.64)

0.073

1.11 (0.80–1.53)

0.528

  1. Values in parentheses are 95% CI. OS from date of diagnosis of liver metastases
  2. aContinuous variable
  3. bExcluding unknown T-stage (n = 32)
  4. cExcluding unknown nodal stage (n = 31)
  5. dIncluding rectal cancer