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Table 5 Univariate and multivariate Cox regression analysis of factors influencing OS in patients with CRCLM

From: Colorectal cancer liver metastases – a population-based study on incidence, management and survival

  Univariate analysis Multivariate analysis
Hazard ratio P Hazard ratio P
Age (years)a 1.03 (1.02–1.05) <0.001 1.03 (1.01–1.05) 0.002
Sex
 Female 1.00 (reference)   1.00 (reference)  
 Male 0.80 (0.62–1.04) 0.099 0.91 (0.65–1.28) 0.598
Tumour stageb
 T1-T2 1.00 (reference)    
 T3-T4 1.03 (0.56–1.89) 0.929
Nodal stagec
 N0 1.00 (reference)   1.00 (reference)  
 N1-N2 1.65 (1.10–2.46) 0.014 0.89 (0.57–1.37) 0.586
Primary tumour origin
 Right-sided 1.00 (reference)   1.00 (reference)  
 Left-sidedd 0.51 (0.39–0.68) <0.001 0.56 (0.39–0.79) 0.001
Time of detection of liver metastases
 Metachronous 1.00 (reference)   1.00 (reference)  
 Synchronous 1.49 (1.14–1.94) 0.004 0.91(0.64–1.30) 0.606
Size of largest liver metastasis (mm)
 < 50 mm 1.00 (reference)   1.00 (reference)  
 > 50 mm 3.07 (2.34–4.03) <0.001 2.51 (1.73–3.65) <0.001
Number of liver metastases
 1–2 1.00 (reference)   1.00 (reference)  
 3–4 1.06 (0.67–1.68) 0.800 1.06 (0.60–1.89) 0.836
  ≥ 5 2.83 (2.12–3.77) 0.000 1.41 (0.94–2.11) 0.095
Liver resection
 No 1.00 (reference)   1.00 (reference)  
 Yes 0.14 (0.10–0.21) <0.001 0.21 (0.13–0.33) <0.001
Lung metastases
 No 1.00 (reference)   1.00 (reference)  
 Yes 1.26 (0.98–1.64) 0.073 1.11 (0.80–1.53) 0.528
  1. Values in parentheses are 95% CI. OS from date of diagnosis of liver metastases
  2. aContinuous variable
  3. bExcluding unknown T-stage (n = 32)
  4. cExcluding unknown nodal stage (n = 31)
  5. dIncluding rectal cancer