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Table 1 Clinical characteristics in patients with tumor cell or lymphocyte PD-L1 expression

From: Heterogeneity of PD-L1 expression in primary tumors and paired lymph node metastases of triple negative breast cancer

Variable

Overall

PD-L1

PT-Infiltrating immune cell(+)

PT-tumor cell (+)

LNM-lymphocyte(+)

LNM-tumor cell(+)

N

%

N

%

p

N

%

p

N

%

p

N

%

p

 

101

 

31

30.69

 

26

25.74

 

54

53.46

 

41

40.59

 

Age, years

    

0.667

  

0.823

  

0.841

  

0.543

  ≤ 50

45

44.55

15

48.39

 

11

42.31

 

25

46.30

 

20

48.78

 

  > 50

56

55.46

16

51.61

 

15

57.69

 

29

53.70

 

21

51.22

 

Menopausal Status

    

0.661

  

1

  

0.689

  

0.410

 Post

60

59.41

17

54.84

 

15

57.69

 

31

57.41

 

22

53.66

 

 Pre

41

40.59

14

45.16

 

11

42.31

 

23

42.59

 

19

46.34

 

Tumor size

    

1

  

0.816

  

0.541

  

0.149

  ≤ 2 cm

38

37.62

12

38.71

 

9

34.62

 

22

40.74

 

19

46.34

 

  > 2 cm

63

62.38

19

61.29

 

17

65.38

 

32

59.26

 

22

53.66

 

Histological grade

    

0.031

  

0.130

  

1

  

0.175

 II

28

27.72

4

12.90

 

4

15.38

 

15

27.78

 

8

19.51

 

 III

73

72.28

27

87.10

 

22

84.62

 

39

72.22

 

33

80.49

 

Node status

    

0.198

  

0.545

  

0.623

  

0.280

 pN1 (1–3 LNs)

52

51.49

19

61.29

 

16

61.54

 

30

55.55

 

25

61.98

 

 pN2 (4–9 LNs)

29

28.71

9

29.03

 

6

23.08

 

15

27.78

 

10

24.39

 

 pN3 (≥10 LNs)

20

19.80

3

9.68

 

4

15.38

 

9

16.67

 

6

14.63

 

TIL score(%)

    

0.020

  

0.001

  

0.399

  

0.042

 0–10

60

59.41

12

38.71

 

7

26.92

 

32

59.26

 

21

51.22

 

 11–20

22

21.78

10

32.26

 

10

38.46

 

14

25.93

 

14

34.15

 

  ≥ 21

19

18.81

9

29.03

 

9

34.62

 

8

14.81

 

6

14.63

 

Local recurrence

    

0.506

  

0.072

  

0.134

  

0.013

 absence

89

88.12

26

83.87

 

20

76.92

 

45

83.33

 

32

78.05

 

 presence

12

11.88

5

16.13

 

6

23.08

 

9

16.67

 

9

21.95

 

Distant metastasis

    

0.797

  

0.592

  

0.033

  

0.094

 absence

78

77.23

23

74.19

 

19

73.08

 

37

68.52

 

28

68.29

 

 Presence

23

22.77

8

25.81

 

7

26.92

 

17

31.48

 

13

31.71

 
  1. Abbreviations: PD-L1 programmed cell death ligand 1, PT primary tumor, LNM lymph node metastasis, TIL tumor infiltrating lymphocyte
  2. p-value of less than 0.05 was considered statistically significant