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Table 1 Clinical characteristics in patients with tumor cell or lymphocyte PD-L1 expression

From: Heterogeneity of PD-L1 expression in primary tumors and paired lymph node metastases of triple negative breast cancer

Variable Overall PD-L1
PT-Infiltrating immune cell(+) PT-tumor cell (+) LNM-lymphocyte(+) LNM-tumor cell(+)
N % N % p N % p N % p N % p
  101   31 30.69   26 25.74   54 53.46   41 40.59  
Age, years      0.667    0.823    0.841    0.543
  ≤ 50 45 44.55 15 48.39   11 42.31   25 46.30   20 48.78  
  > 50 56 55.46 16 51.61   15 57.69   29 53.70   21 51.22  
Menopausal Status      0.661    1    0.689    0.410
 Post 60 59.41 17 54.84   15 57.69   31 57.41   22 53.66  
 Pre 41 40.59 14 45.16   11 42.31   23 42.59   19 46.34  
Tumor size      1    0.816    0.541    0.149
  ≤ 2 cm 38 37.62 12 38.71   9 34.62   22 40.74   19 46.34  
  > 2 cm 63 62.38 19 61.29   17 65.38   32 59.26   22 53.66  
Histological grade      0.031    0.130    1    0.175
 II 28 27.72 4 12.90   4 15.38   15 27.78   8 19.51  
 III 73 72.28 27 87.10   22 84.62   39 72.22   33 80.49  
Node status      0.198    0.545    0.623    0.280
 pN1 (1–3 LNs) 52 51.49 19 61.29   16 61.54   30 55.55   25 61.98  
 pN2 (4–9 LNs) 29 28.71 9 29.03   6 23.08   15 27.78   10 24.39  
 pN3 (≥10 LNs) 20 19.80 3 9.68   4 15.38   9 16.67   6 14.63  
TIL score(%)      0.020    0.001    0.399    0.042
 0–10 60 59.41 12 38.71   7 26.92   32 59.26   21 51.22  
 11–20 22 21.78 10 32.26   10 38.46   14 25.93   14 34.15  
  ≥ 21 19 18.81 9 29.03   9 34.62   8 14.81   6 14.63  
Local recurrence      0.506    0.072    0.134    0.013
 absence 89 88.12 26 83.87   20 76.92   45 83.33   32 78.05  
 presence 12 11.88 5 16.13   6 23.08   9 16.67   9 21.95  
Distant metastasis      0.797    0.592    0.033    0.094
 absence 78 77.23 23 74.19   19 73.08   37 68.52   28 68.29  
 Presence 23 22.77 8 25.81   7 26.92   17 31.48   13 31.71  
  1. Abbreviations: PD-L1 programmed cell death ligand 1, PT primary tumor, LNM lymph node metastasis, TIL tumor infiltrating lymphocyte
  2. p-value of less than 0.05 was considered statistically significant