Moesin expression by tumor cells is an unfavorable prognostic biomarker for oral cancer

BMC Cancer

Table 1 Expression of podoplanin and moesin at invasive tumor front of 84 oral squamous cell carcinoma, according to clinical data and follow-up. A.C. Camargo Cancer Hospital, São Paulo, Brazil, 1963 to 2012

Variable	Moesin				p	Podoplanin				p
	Weak		Strong			Weak		Strong
	N	%	N	%		N	%	N	%
Gender
Male	35	87.5	37	84.1	0.656	45	91.8	27	77.1	0.058
Female	5	12.5	7	15.9	0.656	4	8.2	8	22.9	0.058
Age
≤ 58 years	22	55	20	45.5	0.382	24	49	18	51.4	0.825
> 58 years	18	45	24	54.5	0.382	25	51	17	48.6	0.825
White	39	97,5	41	93.2	0.618	46	93.9	34	97.1	0.637
Non-white	1	2,5	3	6.8	0.618	3	6.1	1	2.9	0.637
Tobacco^a
Yes	31	93.9	40	95.2	0.999	43	95.6	28	93.3	0.999
No	2	6.1	2	4.8	0.999	2	4.4	2	6.7	0.999
Alcohol^a
Yes	26	76.5	31	73.8	0.790	32	71.1	25	80.6	0.346
No	8	23.5	11	26.2	0.790	13	28.9	6	19.4	0.346
T Stage
T2	25	62.5	25	56.8	0.596	27	55.1	23	65.7	0.329
T3	15	37.5	19	43.2	0.596	22	44.9	12	34.3	0.329
N Stage
N0	22	55	21	47.7	0.505	24	49	19	54.3	0.631
N+	18	45	23	52.3	0.505	25	51	16	45.7	0.631
Lymph Node Involvement
No	2	5	1	2.3	0.679	1	2	2	5.7	0.669
Ipsilateral	30	75	36	81.8		39	79.6	27	77.1
Contralateral	8	20	7	15.9		9	18.4	6	17.1
Radiotherapy
Yes	20	50	17	38.6	0.295	21	42.9	26	74.3	*0.004*
No	20	50	27	61.4	0.295	28	57.1	9	25.7	*0.004*
Recurrence
Yes	22	55	21	47.7	0.505	26	53.1	15	42.9	0.356
No	18	45	23	52.3	0.505	23	46.9	20	57.1	0.356
Second Tumor
Yes	10	25	4	9.1	0.061	6	12.2	8	22.9	0.198
No	30	75	40	90.0	0.061	43	87.8	27	77.1	0.198
TOTAL	40	100	44	100		36	100	55	100

N: Number of tumors; p: value obtained by chi-squares test or Fischer’s exact test
^aExcluded patients with lost records
p<0.05 was considered statistically significant

ISSN: 1471-2407