Fig. 4

Intraindividual variability in somatostatin receptor 2 (SSTR2) expression intensity in hepatocellular and cholangiocellular carcinomas and presence of somatostatin receptors (SSTR) and of CXCR4 in surrounding normal tissue and in tumor stroma. a-e Typical example for intraindividual variability of SSTR2 expression intensity in hepatocellular carcinomas. All photomicrographs were taken from the same tumor slide. Immunohistochemistry (red-brown color), counterstaining with hematoxylin; scale bar: A: 60 μm, B-E: 50 μm. f, j Presence of SSTR2 and of CXCR4 in germinal centers of lymph follicles (arrows) in close vicinity to (largely negative) tumor cells (arrowheads). g, h SSTR5 and CXCR4 expression in tumor vessels. i Strong CXCR4 staining of infiltrating lymphocytes (arrows). Immunohistochemistry (red-brown color), counterstaining with hematoxylin; scale bar: 50 μm