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Table 2 Logistic Regression Models of FISH Only and FISH with Clinical Parameters (NCCN Risk Groups). Odds ratios, the corresponding confidence limits (CL) and p values are provided for both predictor variables (FISH and NCCN Risk Groups, respectively) in the second model. If any of the FISH parameters in the combination is greater than or equal to the cut-off, the specimen is considered positive; if all FISH parameters in the combination are below the cut-off, the specimen is considered negative

From: Identification of fluorescence in situ hybridization assay markers for prediction of disease progression in prostate cancer patients on active surveillance

FISH Parameter Combination

n Cases

n Controls

FISH Only Model

FISH With Clinical Parameters Model

Odds Ratio

95% Wald Lower CL

95% Wald Upper CL

p Value

FISH

NCCN Risk Groups

Odds Ratio

95% Wald Lower CL

95% Wald Upper CL

p Value

Odds Ratio

95% Wald Lower CL

95% Wald Upper CL

p Value

MYC Gain & FGFR1 Gain & PTEN Homozygous

58

49

5.125

2.288

13.308

0.0001

6.221

2.441

15.851

0.0001

4.149

1.339

12.851

0.0136

MYC Gain & PTEN Homozygous & NMYC Gain

61

46

5.631

2.343

14.248

0.0001

5.889

2.299

15.084

0.0002

3.761

1.216

11.635

0.0215

MYC Gain & PTEN Homozygous & NMYC Gain & FGFR1 Gain

55

52

5.647

2.395

12.583

<0.0001

7.005

2.835

17.306

<0.0001

5.141

1.632

16.190

0.0052

MYC Gain & PTEN Homozygous & ETV1 Split

58

49

6.125

2.657

14.119

<0.0001

6.402

2.666

15.374

<0.0001

3.910

1.272

12.021

0.0173

MYC Gain & PTEN Homozygous & NMYC Gain & 2 Edel

62

45

5.173

2.343

14.248

0.0001

5.889

2.299

15.084

0.0002

3.761

1.216

11.635

0.0215

MYC Gain & PTEN Homozygous & NMYC Gain & ETV1 Split

62

45

6.205

2.616

16.831

<0.0001

6.431

2.463

16.789

0.0001

3.429

1.107

10.621

0.0326

MYC Gain & PTEN Homozygous &NMYC Gain & FGFR1 Gain & 2 Edel

63

44

4.761

2.015

10.533

0.0003

5.065

2.110

12.160

0.0003

4.029

1.328

12.224

0.0138