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Table 2 Logistic Regression Models of FISH Only and FISH with Clinical Parameters (NCCN Risk Groups). Odds ratios, the corresponding confidence limits (CL) and p values are provided for both predictor variables (FISH and NCCN Risk Groups, respectively) in the second model. If any of the FISH parameters in the combination is greater than or equal to the cut-off, the specimen is considered positive; if all FISH parameters in the combination are below the cut-off, the specimen is considered negative

From: Identification of fluorescence in situ hybridization assay markers for prediction of disease progression in prostate cancer patients on active surveillance

FISH Parameter Combination n Cases n Controls FISH Only Model FISH With Clinical Parameters Model
Odds Ratio 95% Wald Lower CL 95% Wald Upper CL p Value FISH NCCN Risk Groups
Odds Ratio 95% Wald Lower CL 95% Wald Upper CL p Value Odds Ratio 95% Wald Lower CL 95% Wald Upper CL p Value
MYC Gain & FGFR1 Gain & PTEN Homozygous 58 49 5.125 2.288 13.308 0.0001 6.221 2.441 15.851 0.0001 4.149 1.339 12.851 0.0136
MYC Gain & PTEN Homozygous & NMYC Gain 61 46 5.631 2.343 14.248 0.0001 5.889 2.299 15.084 0.0002 3.761 1.216 11.635 0.0215
MYC Gain & PTEN Homozygous & NMYC Gain & FGFR1 Gain 55 52 5.647 2.395 12.583 <0.0001 7.005 2.835 17.306 <0.0001 5.141 1.632 16.190 0.0052
MYC Gain & PTEN Homozygous & ETV1 Split 58 49 6.125 2.657 14.119 <0.0001 6.402 2.666 15.374 <0.0001 3.910 1.272 12.021 0.0173
MYC Gain & PTEN Homozygous & NMYC Gain & 2 Edel 62 45 5.173 2.343 14.248 0.0001 5.889 2.299 15.084 0.0002 3.761 1.216 11.635 0.0215
MYC Gain & PTEN Homozygous & NMYC Gain & ETV1 Split 62 45 6.205 2.616 16.831 <0.0001 6.431 2.463 16.789 0.0001 3.429 1.107 10.621 0.0326
MYC Gain & PTEN Homozygous &NMYC Gain & FGFR1 Gain & 2 Edel 63 44 4.761 2.015 10.533 0.0003 5.065 2.110 12.160 0.0003 4.029 1.328 12.224 0.0138