Fig. 6

HIF-1α expression in each treatment group. a: control; b: endostatin; c: radiotherapy; d: radiotherapy with endostatin treatment; e: Comparison of the percentages of cells that stained positive for HIF-1α in the four groups. The rates of positive HIF-1α expression in each group were as follows: control group, 66.34% ± 3.23%; endostatin group, 16.43% ± 1.14%; radiotherapy group, 82.14% ± 3.65%; and radiotherapy with endostatin treatment group, 31.35% ± 1.51%. The rate of positive HIF-1α expression in the radiotherapy group was significantly higher than those in the other three groups (n = 8 per group,P < 0.05), while the rates of positive HIF-1α expression in the endostatin and radiotherapy with endostatin treatment groups were significantly decreased compared with that in the control group (n = 8 per group,P < 0.05) (200×)