Table 2 Age at diagnosis of pediatric cancer in families with one - or multiple children with cancer
From: Predominance of girls with cancer in families with multiple childhood cancer cases
Mean age at diagnosis | ||||||
|---|---|---|---|---|---|---|
FAM > 1 | FAM1 | LCCG-study | Gen. Pop. | |||
Diagnosis | years ± SD (n) | years ± SD (n) | p | years ± SD (n) | p | years [24] |
All diagnoses | 7.1 ± 5.2 (86) | 7.2 ± 5.0 (487) | 0.842 | 7.2 ± 5.1 (534) | 0.997 | |
Leukemia | 5.9 ± 4.2 (30) | 5.8 ± 4.3 (154) | 0.974 | 5.8 ± 4.2 (170) | 0.941 | 5.0 |
CNS tumor | 7.6 ± 5.1 (22) | 8.4 ± 4.5 (100) | 0.506 | 8.4 ± 4.6 (110) | 0.449 | 7.0 |
Lymphoma | 13.7 ± 2.7 (11) | 11.0 ± 4.7 (72) | 0.067 | 11.3 ± 4.6 (81) | 0.101 | 10.8 |
Histiocytosis | 3.5 + 1.2 (2) | 4.3 ± 3.7 (11) | 0.783 | 4.2 ± 3.5 (12) | 0.770 | – |
Neuroblastoma | 1.6 ± 1.2 (4) | 2.1 ± 2.7 (22) | 0.721 | 2.1 ± 2.7 (24) | 0.740 | 1.3 |
Retinoblastoma | 0.9 ± 1.0 (3) | 1.4 ± 1.0 (2) | 0.652 | 0.9 ± 0.8 (4) | 0.935 | 1.3 |
Bone tumor | 13.4 ± 5.4 (3) | 10.8 ± 4.9 (40) | 0.370 | 10.8 ± 4.9 (40) | 0.370 | 11.6 |
Hepatic tumor | 2.0 ± 1.0 (3) | 0.7 ± 0.9 (3) | 0.179 | 1.4 ± 1.1 (6) | 0.429 | 1.1 |
Soft tissue sarcoma | 5.3 ± 3.5 (3) | 5.7 ± 4.2 (28) | 0.863 | 5.5 ± 4.1 (30) | 0.910 | 6.5 |
Germ-cell tumors | 12.6 (1) | 8.9 ± 6.8 (11) | 0.611 | 9.2 ± 6.5 (12) | 0.627 | 8.7 |
Carcinomas | 6.0 (1) | 9.2 ± 4.3 (5) | 0.532 | 9.2 ± 4.3 (5) | 0.532 | 111 |
Wilms’ tumor | 6.1 ± 6.2 (3) | 3.6 ± 3.3 (34) | 0.238 | 3.6 ± 3.2 (35) | 0.231 | 3.3 |
Others | - (0) | - (5) | – | - (5) | – | – |