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Table 5 Effect of cisplatin (CP) and different treatments of AHE on testicular tissue protein, and oxidative stress markers

From: Acacia hydaspica ethyl acetate extract protects against cisplatin-induced DNA damage, oxidative stress and testicular injuries in adult male rats

Group

Protein (μg/mg Tissue)

H2O2 (nM/min/mg Tissue)

Nitrite content (NO μM/ml)

MDA (nM/min/mg protein)

Control

1.558 ± 0.01

2.408 ± 0.09

41.97 ± 0.52

3.031 ± 0.12

CP

0.944 ± 0.04***

5.825 ± 0.06***

80.05 ± 0.62***

9.713 ± 0.18***

AHE alone

1.561 ± 0.05+++

2.349 ± 0.02+++

40.92 ± 0.37+++

2.95 ± 0.15+++

CP + AHE

1.352 ± 0.05***,+++,###

4.568 ± 0.02***,+++,###

62.77 ± 0.63***,+++,###

6.015 ± 0.15***,+++,###

AHE + CP

1.516 ± 0.03+++

3.216 ± 0.01***,+++

44.80 ± 0.48*,+++

3.87 ± 0.14**,###

CP + Sily

1.540 ± 0.02+++

3.145 ± 0.01***,+++

44.23 ± 0.76+++

4.058 ± 0.14**,###

  1. n = 6/group; values are expressed as mean ± SEM; *, **, *** indicate significance from the control group at p < 0.05, p < 0.001 and p < 0.0001 probability level, respectively; ++, +++ indicate significance from the CP group at p < 0.001 and p < 0.0001 probability level, respectively; ### indicates comparison of AHE + CP pre-treated group vs. CP + AHE post-treated group at p < 0.0001 probability level. Non-significant difference (p > 0.05) was recorded between control and AHE alone treated group in all parameters (One way ANOVA followed by Tukey’s multiple comparison tests)