Acacia hydaspica ethyl acetate extract protects against cisplatin-induced DNA damage, oxidative stress and testicular injuries in adult male rats

Table 2 Effect of cisplatin (CP) and different treatments of AHE on male reproductive hormones

Group	T (ng/ml)	LH (mIU/ml)	FSH (mIU/ml)
Control	4.55 ± 0.09	2.30 ± 0.04	1.46 ± 0.012
CP	2.32 ± 0.06^***	1.32 ± 0.02^***	0.79 ± 0.035^***
AHE alone	4.59 ± 0.06⁺⁺⁺	2.31 ± 0.04⁺⁺⁺	1.46 ± 0.013⁺⁺⁺
CP + AHE	2.85 ± 0.09^***,+++,###	1.46 ± 0.02^***,+,###	1.00 ± 0.053^***,+++,###
AHE + CP	4.20 ± 0.07^*,+++	2.09 ± 0.06^*,+++	1.32 ± 0.022^*,+++
CP + Sily	4.16 ± 0.04^*,+++	2.08 ± 0.06^**,+++	1.31 ± 0.013^**,+++

n = 6/group; values are expressed as mean ± SEM; ^{*, **, ***} indicate significance from the control group as mean ± SEM at p < 0.05, p < 0.001 and p < 0.0001 probability level, respectively; ^{++, +++} indicate significance from the CP group at p < 0.001 and p < 0.0001 probability level, respectively; ### indicates comparison of AHE + CP pre-treated group vs. CP + AHE post-treated group at p < 0.0001 probability level. Non-signigicant difference was recorded between control and AHE alone group (One way ANOVA followed by Tukey’s multiple comparison)

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