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Fig. 3 | BMC Cancer

Fig. 3

From: Inhibition of p38 MAPK activity leads to cell type-specific effects on the molecular circadian clock and time-dependent reduction of glioma cell invasiveness

Fig. 3

VX-745 inhibits p38 MAPK activity in cultured Per2Luc SCN cells and Bmal1-dLuc fibroblasts. Representative western blots (top) and densitometric analyses (bottom) of p38 MAPK activation in Per2Luc SCN (a) and Bmal1-dLuc fibroblast (b) cultures treated for 1 h with DMSO (CON) (n = 4) or VX-745-treated (10 μM or 20 μM; n = 4) at 4 h or 16 h post-serum shock. Bar graphs depict the ratios of pp38/p38 MAPK immunoreactive signal. Asterisks denote treatment times in which p38 MAPK phosphorylation in VX-745-treated SCN cells or fibroblasts were significantly decreased (p < 0.05) compared to control cultures. OD = optical density

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