Fig. 11

Plexin-A1 konckdown reduce tumor growth in vivo. a-c Representative picture of BALB/c nude mice receiving subcutaneous inoculation of shNC MGC803 cells (a), shPlexin-A1 MGC803 cells (c) or RPMI-1640medium (b) before excising for tumor xenografts. Representative tumor xenografts of shNC MGC803 cells (d) and shPlexin-A1 MGC803 cells (e) excised from mice were shown. There were 6/6 sites (d) tumor formation in siNC group, and 2/6 sites (e) tumor formation in siplexin-A1 group. Weight (f) and Volume (g) of tumor xenografts excised from BALB/c nude mice after plexin-A1 knockdown when compared with xenografts transfected with siNC. h-i Representative images of immunohistochemical staining with DAB show that plexin-A1 (black arrow) highly expressed in siNC group in xenografts (h), but not expressed in siplexin-A1 group (i). Scale bar, 25 μm