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Table 2 Association between smoking behaviors and risk of colorectal cancer

From: Effects of interactions between common genetic variants and smoking on colorectal cancer

Smoking behavior

Men

Women

Case

Control

OR

(95% CI)a

P

Case

Control

OR

(95% CI)a

P

(N = 480)

(N = 960)

(N = 223)

(N = 446)

N

(%)

N

(%)

N

(%)

N

(%)

Smoking status

              

 never smoker

116

(24.2)

191

(19.9)

1.00

(ref.)

 

200

(89.7)

426

(95.5)

1.00

(ref.)

 

 ever (ex- and current) smoker

364

(75.8)

769

(80.1)

0.75

(0.56–1.00)

0.05

23

(10.3)

20

(4.5)

2.23

(1.15–4.34)

0.02

Smoking durationb, years (median)

              

  ≤ 28 in men, ≤15 in women

164

(45.1)

422

(54.9)

1.00

(ref.)

 

8

(34.8)

14

(70.0)

1.00

(ref.)

 

  > 28 in men, > 15 in women

200

(55.0)

347

(45.1)

1.49

(1.11–1.98)

< 0.01

15

(65.2)

6

(30.0)

4.82

(0.97–24.03)

0.05

Amount of smokingb, cigarettes per day (median)

              

  < 20 in men, < 8 in women

123

(33.8)

419

(54.5)

1.00

(ref.)

 

9

(39.1)

13

(65.0)

1.00

(ref.)

 

  ≥ 20 in men, ≥ 8 in women

241

(66.2)

350

(45.5)

2.12

(1.61–2.79)

< 0.01

14

(60.9)

7

(35.0)

3.43

(0.73–16.06)

0.12

Pack-years of smokingb, pack-years (median)

              

  < 21 in men, < 5 in women

134

(36.8)

418

(54.4)

1.00

(ref.)

 

7

(30.4)

12

(60.0)

1.00

(ref.)

 

  ≥ 21 in men, ≥ 5 in women

230

(63.2)

351

(45.6)

1.78

(1.35–2.35)

< 0.01

16

(69.6)

8

(40.0)

6.11

(1.10–34.00)

0.04

  1. Abbreviations: OR odds ratio, CI confidence interval, and ref. reference
  2. aLogistic regression model adjusted for age, family history of colorectal cancer, BMI, and education level
  3. bSmoking behaviors among ever smokers
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BMC Cancer

ISSN: 1471-2407

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