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Table 3 Hazard ratio (HR) of incident colorectal- and colon cancer associated with blood glucose for men and women in the Malmö Diet and Cancer Study cardiovascular cohort

From: High blood glucose levels are associated with higher risk of colon cancer in men: a cohort study

 

Colorectal cancer

nmen = 1992 nwomen = 2981

Colon cancer

nmen = 1958 nwomen = 2888

  

Crude model

Full model

 

Crude model

Full model

Quartiles of glucose

Min-max (mIU/l)

Cases/person-years

HR

95% CI

HR

95% CI

Cases/person-years

HR

95% CI

HR

95% CI

Men

           

 1

3.3–4.5

5/4400

1.00

 

1.00

 

2/4358

1.00

 

1.00

 

 2

4.6–4.8

10/7276

1.28

0.57, 2.90

1.25

0.55, 2.85

4/7216

2.05

0.50, 7.01

1.95

0.57, 6.70

 3

4.9–5.2

16/9835

2.10

0.99, 4.45

2.03

0.95, 4.32

9/9767

2.28

0.67, 7.79

2–08

0.60, 7.17

 4

5.3–16.8

40/10853

3.08

1.54, 6.15

2.80

1.37, 5.70

22/19679

5.40

1.84, 15.87

4.23

1.46, 13.44

p for trend

  

<0.001

 

0.001

  

0.001

 

0.002

 

Women

           

 1

3.4–4.5

20/13981

1.00

 

1.00

 

12/13888

1.00

 

1.00

 

 2

4.6–4.8

20/14048

1.24

0.64, 2.38

1.21

0.62, 2.34

9/13977

0.77

0.29, 2.05

0.73

0.27, 1.96

 3

4.9–5.2

18/12553

0.89

0.47, 1.66

0.82

0.44, 1.55

13/12510

1.08

0.50, 2.34

0.96

0.45, 2.09

 4

5.3–12.2

16/8834

1.16

0.62, 2.17

1.02

0.53, 1.95

10/8797

1.22

0.54, 2.71

1.01

0.44, 2.34

   

0.908

 

0.739

  

0.562

 

0.878

 
  1. Full model: Calculated with the Cox proportional hazard regression model. Adjusted for age (quartiles of age), BMI (≤ 25 kg/m2, > 25 kg/m2), and smoking (current, ex or never)
  2. Values are quartile ranges, hazard ratios (HR), and 95% confidence intervals (CI)