Table 3 Race-specific estimates of colorectal cancer risk associated with family history of colorectal and prostate cancer in the WHI OS
Family History of cancer among 1st degree relatives | White | Black | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Colorectal cancer cases | Non-cases | p-value | Multivariable-adjusted HR (95% CI)a | Colorectal cancer cases | Non-cases | p-value | Multivariable-adjusted HR (95% CI)a | |||||
N | (%) | N | (%) | N | (%) | N | (%) | |||||
Total (78757) | 954 | 2.0 | 62,296 | 98.0 | 98 | 2.0 | 5930 | 98.0 | ||||
Colorectal cancer† | 0.001 | 0.033 | ||||||||||
none | 771 | 80.8 | 52,807 | 84.8 | referent | 77 | 78.6 | 5107 | 86.1 | referent | ||
1 or more relatives | 183 | 19.2 | 9489 | 15.2 | 1.31 (1.11–1.55) | 21 | 21.4 | 823 | 13.9 | 1.80 (1.10–2.93) | ||
Prostate cancerb | 0.805 | 0.576 | ||||||||||
none | 859 | 90.0 | 56,241 | 90.3 | referent | 89 | 90.8 | 5280 | 89.0 | referent | ||
1 or more relatives | 95 | 10.0 | 6055 | 9.7 | 0.97 (0.80–1.22) | 9 | 9.2 | 650 | 11.0 | 0.69 (0.33–1.42) | ||
Colorectal and Prostate cancer | 0.005 | 0.146 | ||||||||||
None | 705 | 73.9 | 48,010 | 77.1 | referent | 72 | 73.5 | 4612 | 77.8 | referent | ||
Colorectal only | 154 | 16.1 | 8231 | 13.2 | 1.28 (1.07–1.52) | 17 | 17.3 | 668 | 11.3 | 1.65 (0.97–2.81) | ||
Prostate only | 66 | 6.9 | 4797 | 7.7 | 0.93 (0.72–1.20) | 5 | 5.1 | 495 | 8.3 | 0.51 (0.19–1.41) | ||
Both | 29 | 3.0 | 1258 | 2.0 | 1.47 (1.00–2.16) | 4 | 4.1 | 155 | 2.6 | 1.76 (0.64–4.81) | ||